Evidence map›Paper›PMID 40129188›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2025

Fetal Body Composition and Organ Volume Trajectories in Association With Maternal Perceived Stress or Depressive Symptoms in the Fetal 3D Study.

Alexandra Jean-Louis, Jessica L Gleason, Zhen Chen, Kathryn A Wagner, William A Grobman, Roger B Newman, Wesley Lee, Robert Gore-Langton, Seth Sherman, John Owen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexandra Jean-LouisEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0009-0004-2922-2261
Jessica L GleasonEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-9877-7931
Zhen ChenBiostatistics and Bioinformatics Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Kathryn A WagnerEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
William A GrobmanDepartment of Obstetrics and Gynecology, Brown University Medical School, Providence, Rhode Island, USA.
Roger B NewmanDepartment of Obstetrics and Gynecology, Division of Reproductive Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID https://orcid.org/0000-0003-0235-987X
Wesley LeeDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
Robert Gore-LangtonThe Emmes Company, Rockville, Maryland, USA.
Seth ShermanThe Emmes Company, Rockville, Maryland, USA.
John OwenDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Deborah A WingDivision of Obstetrics & Gynecology and Maternal-Fetal Medicine, University of California Irvine, Irvine, California, USA.
Daniel W SkupskiDepartment of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York, USA.
Jagteshwar GrewalDivision of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Katherine L GrantzEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

Funding

The National Standard for Normal Fetal GrowthZIAHD008852 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI GRANTZ, KATHERINE · 2009 to 2025
$5.6M
Fetal 3D StudyZIAHD008956 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI GRANTZ, KATHERINE · 2016 to 2025
$3.1M
Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD008852Intramural NIH HHS ZIA HD008956NICHD NIH HHS HHSN275200800002CNICHD NIH HHS HHSN275200800002INICHD NIH HHS HHSN275200800003CNICHD NIH HHS HHSN275200800003INICHD NIH HHS HHSN275200800012CNICHD NIH HHS HHSN275200800013CNICHD NIH HHS HHSN275200800014CNICHD NIH HHS HHSN275200800028CNICHD NIH HHS HHSN275201000009CNICHD NIH HHS HHSN275201300026INICHD NIH HHS HHSN275201500002CNICHD NIH HHS HHSN275201500002I
6 · The paper itself

Abstract

objectivesEvaluate associations between maternal perceived stress and depressive symptoms, and fetal body composition and organ volumes.

methodsIn the NICHD Fetal 3D Study (2015-2019; n = 2457), stress and depressive symptoms were assessed at enrollment (10-13 weeks). High stress was defined as a Perceived Stress Scale (PSS) score ≥15 and high depressive symptoms, defined as an Edinburgh Postnatal Depression Scale (EPDS) score ≥10. Fetal body composition and organ volumes (cerebellar, lung, liver, and kidney) were measured up to five times between 15 and 40 weeks using three-dimensional (3D) ultrasound technology. Trajectories of body composition and organ volumes across pregnancy by high versus low PSS and EPDS were created using linear mixed models. Overall and weekly differences were compared after adjusting for covariates.

resultsSix hundred (24.4%) women scored ≥15 on the PSS, and 334 (13.6%) scored ≥10 on the EPDS. Fetuses whose mothers had PSS ≥15 had 0.4-0.9 cm

conclusionsGreater maternal perceived stress and depressive symptoms early in pregnancy were associated with up to an 8.0 cm

Indexed as

Body CompositionDepressionFetusImaging, Three-DimensionalPregnancy ComplicationsStress, PsychologicalUltrasonography, PrenatalAdultFemaleHumansOrgan SizePregnancybody compositionfetal developmentfetal growthmaternal psychosocial distressorgan growth

Identifiers

PMID40129188
PMCPMC12151757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.