Evidence map›Paper›PMID 40129165›Full record

SynthesisThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2026

A Review and Meta-Analysis on Altered Brain Structure in Patients Born with Non-Syndromic Cleft Lip and/or Palate.

N N Homoud, A J Ireland, M Sherriff, Z AlSaffar, A J V Davies, J R Sandy

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07330687 (A Brain Imaging Study of Abnormal Neural Network Reorganization Following Speech Training in Patients With Compensatory Articulation Secondary to Cleft Palate), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07330687 nacompletednot on this map

A Brain Imaging Study of Abnormal Neural Network Reorganization Following Speech Training in Patients With Compensatory Articulation Secondary to Cleft Palate

TypeinterventionalSponsorShufan ZhaoRan2019 to 2021Enrolled164ConditionsCleft Lip and/or Palate, Speech Disorder, Speech Therapy, BrainArmsStructured Speech Training for Decompensation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

N N HomoudBristol Dental School, The University of Bristol, Bristol, UK.ORCID 0009-0002-2016-905X
A J IrelandBristol Dental School, The University of Bristol, Bristol, UK.
M SherriffBristol Dental School, The University of Bristol, Bristol, UK.ORCID 0000-0003-3737-1449
Z AlSaffarBristol Dental School, The University of Bristol, Bristol, UK.
A J V DaviesBristol Dental School, The University of Bristol, Bristol, UK.ORCID 0000-0001-7234-0539
J R SandyBristol Dental School, The University of Bristol, Bristol, UK.ORCID 0000-0001-7144-9700

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo determine if there is evidence for a relationship between the presence of a non-syndromic cleft lip and/or palate (NSCL/P) and altered brain structure in cleft affected individuals.DesignElectronic database (MEDLINE; EMBASE; Cochrane library) and manual searches were performed and were limited to English language texts published between 1st of January 1969 until 1st of June 2024. Data extraction and risk of bias assessment were carried out independently by two reviewers. A meta-analysis on 9 publications was performed using a random effects model.Main outcome measureComparison of brain structure between patients born with cleft lip and/or palate and unaffected healthy individuals.ResultsThe review identified 11 studies, of which 9 were included in the meta-analysis. The latter comprised 398 individuals with NSCL/P compared to 458 unaffected controls. There was statistical evidence to suggest a reduction in the overall intracranial volume and the total cerebellar volume in the NSCL/P cases compared to the controls (Hedges'

Indexed as

BrainCleft LipCleft PalateHumansMagnetic Resonance ImagingbrainCLOCL/PCPmeta-analysisNSCL/Preview

Identifiers

PMID40129165
PMCPMC13076961

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.