Evidence map›Paper›PMID 40129142›Full record

ArticleRecent patents on anti-cancer drug discovery2025

Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches.

Mohammed Abdalla Hussein, Gamila A Farouk, Haneen Kh Abdelkader, Mina A Daniel, Mohamed A Youssef, Gaber E Eldesoky, Seikh Mafiz Alam, Mohammad Shahidul Islam, Yasser O Mosaad

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Article in Recent patents on anti-cancer drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed Abdalla HusseinBiotechnology Department, Faculty of Applied Health Sciences, October 6 University, Sixth of October City, Egypt.ORCID 0000-0002-1811-2794
Gamila A FaroukBiotechnology Department, Faculty of Applied Health Sciences, October 6 University, Sixth of October City, Egypt.
Haneen Kh AbdelkaderBiotechnology Department, Faculty of Applied Health Sciences, October 6 University, Sixth of October City, Egypt.
Mina A DanielBiotechnology Department, Faculty of Applied Health Sciences, October 6 University, Sixth of October City, Egypt.
Mohamed A YoussefBiotechnology Department, Faculty of Applied Health Sciences, October 6 University, Sixth of October City, Egypt.
Gaber E EldesokyDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Seikh Mafiz AlamDepartment of Chemistry, Aliah University, New Town, Kolkata, 700 156, India.
Mohammad Shahidul IslamDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Yasser O MosaadPharmacology Department, Faculty of Pharmacy, Future University, Cairo City, Egypt.

Funding

King Saud University, Riyadh, Saudi Arabia RSPD2025R1100
6 · The paper itself

Abstract

backgroundColorectal cancer is a significant global public health challenge, contributing substantially to cancer-related mortality worldwide. Vitexin has been shown to promote the polarization of macrophages towards the M1 phenotype, a process dependent on the Vitamin D receptor. This polarization is crucial in the tumor microenvironment, as it helps mitigate the progression from chronic colitis to colorectal cancer. Despite its potential, the mechanisms of vitexin's action and its impact on colon cancer remain unclear.

objectiveThis study aims to evaluate the inhibitory effects of vitexin on cell proliferation and apoptosis in the Caco-2 colon cancer cell line, with a specific focus on its modulation of antioxidant enzyme activities, pro-apoptotic factors, and key signaling pathways involved in cell survival and proliferation.

methodsThe IC

resultsVitexin exhibited an IC

conclusionThis study demonstrates that vitexin induces apoptosis in Caco-2 colon cancer cells through multiple mechanisms, including modulation of antioxidant enzymes, upregulation of pro-apoptotic factors, and regulation of key signaling pathways involved in cell survival and proliferation. These findings suggest that vitexin's mechanisms of action involve complex interactions with various cellular pathways, making it a promising candidate for further research and potential therapeutic applications in colorectal cancer.

Indexed as

AMP-Activated Protein KinasesApigeninApoptosisColonic NeoplasmsTOR Serine-Threonine KinasesCaco-2 CellsCell ProliferationCell SurvivalHumansSignal TransductionAMP-Activated Protein KinasesApigeninMTOR protein, humanTOR Serine-Threonine KinasesvitexinAktAMPKapoptosisCaco-2 cellscolon cancermTORp53PI3K proteins.PUMAVitexin

Identifiers

PMID40129142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.