Evidence map›Paper›PMID 40129108›Full record

ArticleInternational wound journal2025

Epidemiology and the Medical Burden of Diabetic Foot Ulcers Especially in Patients With Infection-A Population-Based Analysis From Germany.

Jürgen Wernecke, Marie Wernecke, Olaf Ebenau, Bastian Spruth, Mareike Krämer, Tobias Vogelmann, York Zöllner

Abstract read
In one paragraph

Article in International wound journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jürgen WerneckeClinic for Diabetes, Agaplesion Diakonieklinikum Hamburg, Hamburg, Germany.
Marie WerneckeClinic for Diabetes, Agaplesion Diakonieklinikum Hamburg, Hamburg, Germany.
Olaf EbenauBSN medical GmbH (Essity Group), Hamburg, Germany.
Bastian SpruthBSN medical GmbH (Essity Group), Hamburg, Germany.
Mareike KrämerLinkCare GmbH, Ludwigsburg, Germany.
Tobias VogelmannLinkCare GmbH, Ludwigsburg, Germany.
York ZöllnerDepartment of Health Sciences, Hamburg University of Applied Sciences, Hamburg, Germany.

Funding

BSN medical GmbH (Essity Group), Germany
6 · The paper itself

Abstract

Due to limited data on the epidemiology of diabetic foot ulcers (DFU) in Germany, especially for those infected, the study determined the prevalence and incidence of DFU and the associated medical burden. Anonymised claims data of 3.3 million insured lives were sourced from a statutory health insurance fund. Patients with DFU between 04/01/2016 and 12/31/2019 were selected (n = 7764) and divided into patients with/without infection/with prophylactic use of antibiotics. Outcome variables were described categorically. Two-sided t-tests and chi-squared tests (p < 0.05) were performed. The prevalence and incidence in patients with DFU was 4.6% and 2.1%, respectively. The mean Charlson Comorbidity Index was 7.9, significantly higher in those infected than in those uninfected (8.1% vs. 7.2%, p < 0.0001). Amputations occurred significantly more often in DFU patients with infection than in those without (minor 25.4% vs. 3.0%, p < 0.0001; major 6.7% vs. 1.2%, p < 0.0001). The 5-year mortality rate was significantly higher in patients with infection than in those without (64.0% vs. 51.3%, p < 0.0001). The occurrence of comorbidities and complications associated with DFU, in particular the high overall medical burden and mortality rate-especially in DFU patients with infections-underscores the importance of prevention and early, appropriate treatment.

Indexed as

Cost of IllnessDiabetic FootAdultAgedAged, 80 and overAmputation, SurgicalFemaleGermanyHumansIncidenceMaleMiddle AgedPrevalenceRetrospective Studiesclaims analysisdiabetes mellitusdiabetic footdiabetic foot ulcermedical burden of disease

Identifiers

PMID40129108
PMCPMC11932955

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.