Evidence map›Paper›PMID 40129092›Full record

ArticleHippocampus2025

Associations Between Episodic Memory and Hippocampal Volume in Late Adulthood.

Sarah L Aghjayan, Sarah E Polk, Hayley S Ripperger, Haiqing Huang, Lu Wan, Thomas Kamarck, Anna L Marsland, Chaeryon Kang, Michelle W Voss, Bradley P Sutton and 7 more

Abstract read
In one paragraph

Article in Hippocampus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sarah L AghjayanDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8597-2022
Sarah E PolkCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Hayley S RippergerDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Haiqing HuangAdventHealth Research Institute, Department of Neuroscience, AdventHealth, Orlando, Florida, USA.
Lu WanAdventHealth Research Institute, Department of Neuroscience, AdventHealth, Orlando, Florida, USA.
Thomas KamarckDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anna L MarslandDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chaeryon KangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Michelle W VossDepartment of Psychological and Brain Science, University of Iowa, Iowa, Iowa, USA.ORCID 0000-0002-3706-7423
Bradley P SuttonBioengineering Department, University of Illinois, Champaign, Illinois, USA.
Lauren E OberlinAdventHealth Research Institute, Department of Neuroscience, AdventHealth, Orlando, Florida, USA.
Jeffrey M BurnsDepartment of Neurology, University of Kansas Medical Center, Kansas, USA.
Eric D VidoniDepartment of Neurology, University of Kansas Medical Center, Kansas, USA.ORCID 0000-0001-5181-7131
Edward McAuleyDepartment of Kinesiology, University of Illinois, Champaign, Illinois, USA.
Charles H HillmanDepartment of Psychology, Northeastern University, Boston, Massachusetts, USA.
Arthur F KramerDepartment of Kinesiology, University of Illinois, Champaign, Illinois, USA.
Kirk I EricksonDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Investigating Gains in Neurocognition in an Intervention Trial of Exercise SupplementR01AG053952 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURNS, JEFFREY MURRAY, ERICKSON, KIRK I · 2016 to 2020
$27.5M
Physical Activity and Dementia: Mechanisms of ActionR35AG072307 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2021 to 2025
$3.6M
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital TherapeuticsK23MH129882 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Lauren Elizabeth Oberlin · 2023 to 2026
$775k
Andrew W. Mellon FoundationNIA NIH HHS R01 AG053952NIA NIH HHS R35 AG072307NIH HHS R01AG053952NIMH NIH HHS K23 MH129882
6 · The paper itself

Abstract

Different tasks of episodic memory (EM) are only moderately correlated with each other. Furthermore, various EM tasks exhibit disproportional relationships with the hippocampus. This study examined the covariance structure of EM tasks and assessed whether this structure relates differently to hippocampal volume (HV) in a sample of 648 cognitively unimpaired older adults (mean age = 69.88). A confirmatory factor analysis (CFA) and linear regression models were used to test the associations between the observed factors of EM and HV. A model with three first-order subfactors (immediate verbal recall, delayed verbal recall, and visuospatial) derived from a second-order EM domain factor satisfied model fit (χ

Indexed as

AgingHippocampusMemory, EpisodicAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMental RecallMiddle AgedNeuropsychological TestsOrgan Sizeepisodic memoryfactor analysishippocampusolder adultsvolumetric

Identifiers

PMID40129092
PMCPMC12001747

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.