Evidence map›Paper›PMID 40128799›Full record

ArticleNeuro-oncology2025

SOX2 commands LIM homeobox transcription factors in choroid plexus development and tumorigenesis.

Lukas J Faltings, Fengjuan Lin, Mariam Zahran, Heena Jalili, Anjali Siluveru, Mahek Chaudry, Leah M Wachsmuth, Navjot Guru, Melanie Schoof, Ping Cao and 12 more

Abstract read
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In one paragraph

Article in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lukas J FaltingsDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Fengjuan LinDepartment of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Mariam ZahranDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Heena JaliliDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Anjali SiluveruDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Mahek ChaudryDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Leah M WachsmuthDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Navjot GuruDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Melanie SchoofInstitute for Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ping CaoDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Yuan HuangDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Noreen MianDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Sohyun MoonDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Asmaa ZahranDepartment of Biology, College of Arts and Science, Adelphi University, Garden City, New York, USA.
Kristen GreenDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Siddhi ModiDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Maheen UmerDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
James Q VirgaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Ying-Tao ZhaoDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
Ulrich SchüllerInstitute for Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-8731-1121
Qun LiDepartment of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Haotian ZhaoDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.ORCID 0000-0003-2315-8452

Funding

(PQ1) Molecular circuit of multi-ciliogenesis regulates choroid plexus differentiation and tumor developmentR01CA220551 · NCI · SANFORD RESEARCH/USD · PI ZHAO, HAOTIAN · 2017 to 2021
$1.7M
MicroRNA 34/449 family plays a critical role in choroid plexus differentiation and tumorigenesisR15CA287297 · NCI · NEW YORK INST OF TECHNOLOGY · PI ZHAO, HAOTIAN · 2025 to 2025
$459k
Astrocytic Heparan Sulfate 6-O-Sulfation in Brain FunctionR15NS130456 · NINDS · NEW YORK INST OF TECHNOLOGY · PI ZHAO, JERRY YINGTAO · 2023 to 2023
$428k
National Natural Science Foundation of China 82173263NCI NIH HHS R01 CA220551NCI NIH HHS R15 CA287297NIH HHS R15NS130456-01 to Y.Z., R01CA220551NINDS NIH HHS R15 NS130456
6 · The paper itself

Abstract

backgroundChoroid plexus (CP) tumors are rare brain neoplasms that mainly affect the pediatric population. Unlike benign CP papilloma (CPP), CP carcinoma (CPC) is an aggressive cancer with a dismal survival rate. Despite chromosome-wide rearrangements, drivers of most CP tumors remain elusive except recurrent alterations in TP53. Studies of signaling dysregulation may bring biological understanding of these malignancies. Previous studies implicated NOTCH signaling in CP tumors; we developed mouse models of CP tumors driven by NOTCH activation and Trp53 loss, respectively. This work examined the role of the transcription factor SOX2 in CP development and tumorigenesis.

methodsMulti-omics approaches were used to characterize cellular heterogeneity in NOTCH-driven CP tumors. SOX2 functions in the molecular signature of tumor cells were investigated.

resultsSingle-cell transcriptomics and epigenetics methods identified diverse cell populations in tumors that resemble normal CP, such as epithelial and glial groups. Pseudotime trajectory analysis indicated that NOTCH-driven CP tumor arises from bipotential glial progenitors and retains a progenitor-like signature characterized by an enhanced SOX2 profile. SOX2 inactivation attenuated progenitor-like features and blunted tumor growth. Integrative omics studies revealed SOX2 binding to genes expressed in progenitors in the rhombic lip, including LIM homeobox transcription factors LMX1A and LMX1B. Consistently, SOX2 maintains progenitor identity through regulating their expression in CP tumors and during development, whereas LMX1A and LMX1B support SOX2 functions in tumor cell proliferation. Furthermore, spatial transcriptomics revealed aberrant SOX2 and LMX1A expression in human CP tumors.

conclusionsSOX2-LMX1 signaling maintains progenitor identity in CP development and tumor formation.

Indexed as

CarcinogenesisChoroid PlexusChoroid Plexus NeoplasmsLIM-Homeodomain ProteinsSOXB1 Transcription FactorsAnimalsGene Expression Regulation, NeoplasticHumansMiceSignal TransductionLIM-Homeodomain ProteinsSOX2 protein, humanSox2 protein, mouseSOXB1 Transcription Factorschoroid plexus tumorLMX1ALMX1BNOTCHSOX2

Identifiers

PMID40128799
PMCPMC12448815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.