ArticleBMC public health2025
Association between combined exposure to organochlorine pesticides and history of uterine fibroids in NHANES: findings from four statistical models.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundOrganochlorine pesticides (OCPs) are extensively dispersed throughout the environment, which potentially have harmful impacts on the female reproductive system. Therefore, the purpose of this study was to clarify the association between exposure to OCPs and the history of uterine fibroids in American women.
methodsThe present study comprised female individuals who were over 20 years old and were selected from the National Health and Nutrition Examination Survey (NHANES). The logistic regression models were used to investigate the associations between eight primary serum OCP compounds and uterine fibroids. The collective impact of OCP compounds on the overall association with uterine fibroids was assessed using three statistical approaches: weighted quantile sum regression (WQS), quantile g-computation model (Qgcomp), and Bayesian kernel machine regression (BKMR) model.
resultsIn the end, a total of 931 individuals were included in the analysis. Out of the total, 126 participants were identified as patients with uterine fibroids. Upon accounting for covariables, the logistic regression analysis revealed a positive association between the highest tertiles of OCP compounds and ln-transformed OCP compounds and the history of uterine fibroids. The analysis of WQS and Qgcomp showed that a 25% increase in the mixture of OCPs was associated with a higher likelihood of having a history of uterine fibroids, with odds ratios (ORs) of 1.49 (95% CI: 1.02, 2.19) and 1.64 (95% CI: 1.15, 2.35), respectively. The primary factor behind this association was oxychlordane. In addition, the overall findings of BKMR demonstrated a consistent and increasing pattern, indicating a robust positive association between the amount of serum OCP compounds and the history of uterine fibroid.
conclusionOur study conclusively established associations between OCPs and history of uterine fibroid. The simultaneous exposure to these chemicals is associated with an increased prevalence of uterine fibroid. Among these chemicals, oxychlordane has the most impact on the overall combined effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.