ArticleBMC genomics2025
Systematic revelation and meditation on the significance of long exons using representative eukaryotic genomes.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Genome-Wide Identification and Expression Analysis of the NIN-LIKE Protein (NLP) Gene Family in Salvia Miltiorrhiza.Biochemical genetics · 2026Article
- Different mRNAs encoding identical proteins: how and why?Journal of applied genetics · 2026Article
- Fascination with RNA Editing: In the Lights of Evolution and Biology.Journal of molecular evolution · 2025Review
- Signal peptides restrict genome evolution and A-to-I RNA editing.NAR genomics and bioinformatics · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
backgroundLong exons/introns are not evenly distributed in the genome, but the biological significance of this phenomenon remains elusive. MATERIALS AND
methodsExon properties were analyzed in seven well-annotated reference genomes, including human and other representative model organisms: mouse, fruitfly, worm, mouse-ear cress, corn, and rice.
resultsIn all species, last exons in genes tend to be the longest. Additionally, we found that (1) canonical splicing motifs are strongly underrepresented in 3'UTR; (2) Last exons tend to have low GC content; (3) Comparing with other species, first exons in D. melanogaster genes demonstrate lower GC content than internal exons.
conclusionsIt cannot be excluded that last exons of genes exert essential regulatory roles and is subjected to natural selection, exhibiting differential splicing tendency, and GC content compared to other parts of the gene body.
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