Evidence map›Paper›PMID 40128658›Full record

ArticleBMC nephrology2025

Severe acute kidney injury with anuria induced by hypokalemia requiring hemodialysis: a case study.

Seong-Wook Lee, Man-Hoon Han, Mee-Seon Kim, Yong-Jin Kim, You Hyun Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seong-Wook LeeDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Man-Hoon HanDepartment of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Mee-Seon KimDepartment of Pathology, School of Dentistry, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Yong-Jin KimDepartment of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
You Hyun JeonDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Hee-Yeon JungDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Ji-Young ChoiDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Jang-Hee ChoDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Sun-Hee ParkDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Chan-Duck KimDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Yong-Lim KimDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Jeong-Hoon LimDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. jh-lim@knu.ac.kr.ORCID 0000-0001-5517-9886

Funding

Korea Health Industry Development Institute HR22C1832Ministry of Science and ICT, South Korea RS-2024-00449995
6 · The paper itself

Abstract

backgroundHypokalemia can result from various causes, with diarrhea being one of the most common. Although rare, chronic hypokalemia can lead to severe acute kidney injury (AKI) that requires dialysis. Therefore, this case study aims to investigate a patient with rectal cancer who, after concurrent chemoradiotherapy and ileostomy, developed chronic hypokalemia owing to prolonged diarrhea, leading to severe AKI with anuria. CASE PRESENTATION: A 64-year-old man with a history of rectal cancer, ileostomy, and hypertension was admitted for severe AKI with anuria. He had developed severe hypokalemia due to chronic diarrhea. Despite having no prior kidney disease, his serum creatinine increased to 4.8 mg/dL, and potassium dropped to 2.2 mmol/L. Initial treatment included hemodialysis for anuric AKI with metabolic acidosis. A kidney biopsy revealed renal tubular vacuolization and With-no-lysine kinase (WNK) bodies in the distal tubules, which are characteristic of hypokalemic nephropathy. Potassium replacement therapy led to a gradual recovery of potassium levels and kidney function.

conclusionThis case highlights the importance of timely diagnosis and management of hypokalemic nephropathy through kidney biopsy.

Indexed as

Acute Kidney InjuryAnuriaHypokalemiaRenal DialysisDiarrheaHumansIleostomyMaleMiddle AgedRectal NeoplasmsSeverity of Illness IndexAcute kidney injuryAnuriaHypokalemic nephropathyKidney biopsyVacuolizationWNK bodies

Identifiers

PMID40128658
PMCPMC11934709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.