ReviewPediatric research2025
Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art.
Review in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07305350 (EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY), which is not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of melatonin in management of hypoxic ischemic encephalopathy (hie) in neonates
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- RECOVER Guidelines: Newborn Resuscitation in Dogs and Cats. Evidence and Knowledge Gap Analysis With Treatment Recommendations.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2025Pooled it
- Predictors of outcome following neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Pediatric spasticity in Brazil: insights from a neurosurgical referral center.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Mast Cell-Microglia Crosstalk Drives Aberrant Synaptic Pruning Through PAR-2/MAPK/NF-κB Signaling in Neonatal Hypoxic-Ischemic Encephalopathy.CNS neuroscience & therapeutics · 2026Article
- Antenatal strategies for prevention of neonatal hypoxic-ischemic encephalopathy: potential role of metformin.Clinical and experimental pediatrics · 2026Article
- Maternal metformin protects developing auditory brainstem function after neonatal hypoxia-ischemia in a neonatal rat model.Clinical and experimental pediatrics · 2026Article
- In-hospital mortality and associated factors among term neonates with documented perinatal asphyxia in eastern Democratic Republic of the Congo: a retrospective cohort study.Tropical medicine and health · 2026Article
- Nothing about us without us: advancing family-centered research and care in neonatal encephalopathy.Pediatric research · 2026Article
- German Hypothermia Registry Improves Clinician Confidence and Harmonises Decentralised Neonatal Hypoxic-Ischaemic Encephalopathy Care in Germany.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Magnesium Sulfate in Neonatal Hypoxic-Ischemic Encephalopathy: Bridging the Gap Between Molecular Neuroprotection and Clinical Outcomes.Current issues in molecular biology · 2026Review
- Whole-Blood Gene Expression and Hypoxic-Ischemic Encephalopathy at Birth.JAMA network open · 2026Article
- Review
- A Differentiated SH-SY5Y Model of Hypoxic-Ischaemic Injury Reveals Dynamic Transcriptomic Responses During Reoxygenation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?Journal of neuroinflammation · 2026Review
- Long-term disability after neonatal encephalopathy in low-resource settings.Pediatric research · 2026Article
- Advancing child health: forecasting the next great research achievements.Pediatric research · 2026Article
- Diffusion tensor imaging and MR spectroscopy in the evaluation of neonatal encephalopathies.Journal of neonatal-perinatal medicine · 2026Article
- Hypoxic Ischemic Encephalopathy: Hearing Impairment and Related Risk Factors.Journal of clinical medicine · 2026Article
- Mitochondrial dysfunction in neonatal brain injury: from molecular mechanisms to therapeutic interventions.Journal of translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal Encephalopathy (NE) remains a major cause of death and long-term severe disabilities, including epilepsy and cerebral palsy in term and near-term infants. The single most common cause is hypoxic-ischemic encephalopathy (HIE). However, there are many other potential causes, including infection, intracranial hemorrhage, stroke, brain malformations, metabolic disorders, and genetic causes. The appropriate management depends on both the specific cause and the stage of evolution of injury. Key tools to expand our understanding of the timing and causes of NE include aEEG, or even better, video EEG monitoring, neuro-imaging including cranial ultrasound and MRI, placental investigations, metabolic, biomarker, and genetic studies. This information is critical to better understand the underlying causes of NE. Therapeutic hypothermia improves outcomes after HIE, but there is still considerable potential to do better. Careful clinical and pre-clinical studies are needed to develop novel therapeutics and to help provide the right treatment at the right time for this high-risk population. IMPACT: Neonatal encephalopathy is complex and multifactorial. This review seeks to expand understanding of the causes, timing, and evolution of encephalopathy in newborns. We highlight key unanswered questions about neonatal encephalopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.