Evidence map›Paper›PMID 40128391›Full record

ReviewNature neuroscience2025

Integrating multimodal data to understand cortical circuit architecture and function.

Anton Arkhipov, Nuno da Costa, Saskia de Vries, Trygve Bakken, Corbett Bennett, Amy Bernard, Jim Berg, Michael Buice, Forrest Collman, Tanya Daigle and 26 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Neurodatascience: Past, Present, and Future.Data science in science · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Building on models-a perspective for computational neuroscience.Cerebral cortex (New York, N.Y. : 1991) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Anton Arkhipov *Allen Institute, Seattle, WA, USA. antona@alleninstitute.org.ORCID http://orcid.org/0000-0003-1106-8310
Nuno da Costa *Allen Institute, Seattle, WA, USA. nunod@alleninstitute.org.ORCID http://orcid.org/0000-0003-2001-4568
Saskia de Vries *Allen Institute, Seattle, WA, USA. saskiad@alleninstitute.org.ORCID http://orcid.org/0000-0002-3704-3499
Trygve BakkenAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3373-7386
Corbett BennettAllen Institute, Seattle, WA, USA.
Amy BernardThe Kavli Foundation, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2540-1153
Jim BergAllen Institute, Seattle, WA, USA.
Michael BuiceAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2196-1498
Forrest CollmanAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0280-7022
Tanya DaigleAllen Institute, Seattle, WA, USA.
Marina GarrettAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5271-2291
Nathan GouwensAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8429-4090
Peter A GroblewskiAllen Institute, Seattle, WA, USA.
Julie HarrisAllen Institute, Seattle, WA, USA.
Michael HawrylyczAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5741-8024
Rebecca HodgeAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5784-9668
Tim JarskyAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4399-539X
Brian KalmbachAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3136-8097
Jerome LecoqAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0131-0938
Brian LeeAllen Institute, Seattle, WA, USA.
Ed LeinAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9012-6552
Boaz LeviAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8346-872X
Stefan MihalasAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2629-7100
Lydia NgAllen Institute, Seattle, WA, USA.
Shawn OlsenAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9568-7057
Clay ReidAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8697-6797
Joshua H SiegleAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7736-4844
Staci SorensenAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6799-2126
Bosiljka TasicAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6861-4506
Carol ThompsonAllen Institute, Seattle, WA, USA.
Jonathan T TingAllen Institute, Seattle, WA, USA.
Cindy van VelthovenAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5120-4546
Shenqin YaoAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2992-4752
Zizhen YaoAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9361-5607
Christof KochAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6482-8067
Hongkui ZengAllen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0326-5878

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7M
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical NeuronsU01MH130907 · NIMH · ALLEN INSTITUTE · PI ANTON ARKHIPOV, MARINA E. GARRETT · 2022 to 2026
$12.5M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory EntrainmentR01NS122742 · NINDS · ALLEN INSTITUTE · PI ANTON ARKHIPOV, Li-Huei Tsai · 2021 to 2026
$4.1M
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data FormatU24NS124001 · NINDS · ALLEN INSTITUTE · PI ANTON ARKHIPOV, Emad Tajkhorshid · 2021 to 2026
$3.4M
Modeling the structure-function relation in a reconstructed cortical tissueR01EB029813 · NIBIB · ALLEN INSTITUTE · PI ARKHIPOV, ANTON, MIHALAS, STEFAN · 2020 to 2020
$1.3M
National Science Foundation (NSF) 2209873NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB029813U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH130907U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS122742U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U24NS124001
6 · The paper itself

Abstract

In recent years there has been a tremendous growth in new technologies that allow large-scale investigation of different characteristics of the nervous system at an unprecedented level of detail. There is a growing trend to use combinations of these new techniques to determine direct links between different modalities. In this Perspective, we focus on the mouse visual cortex, as this is one of the model systems in which much progress has been made in the integration of multimodal data to advance understanding. We review several approaches that allow integration of data regarding various properties of cortical cell types, connectivity at the level of brain areas, cell types and individual cells, and functional neural activity in vivo. The increasingly crucial contributions of computation and theory in analyzing and systematically modeling data are also highlighted. Together with open sharing of data, tools and models, integrative approaches are essential tools in modern neuroscience for improving our understanding of the brain architecture, mechanisms and function.

Indexed as

Nerve NetVisual CortexAnimalsHumansMiceModels, NeurologicalNeural PathwaysNeurons

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.