ArticleNature communications2025
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
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Who cites it
17 citing papers in PubMed.
- Disrupted thalamic functional hierarchy on resting-state fMRI in idiopathic generalized epilepsy.European radiology experimental · 2026Article
- Cause, Consequence, or Compass? The Thalamus in Temporal Lobe Epilepsy Surgery.Epilepsy currents · 2026Article
- Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy.Epilepsia · 2026Article
- A lesion-derived brain network of somatic symptoms for transdiagnostic individual application.BMC medicine · 2026Article
- Article
- Investigating the methodological foundation of lesion network mapping.Nature neuroscience · 2026Article
- Postictal aggression in epilepsy: prevalence, clinical correlates, and psychosocial impact.Journal of neurology · 2026Article
- Article
- Thalamic organization differentially contributes to clinical conditions in epilepsy.Communications medicine · 2026Article
- Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy.Neurology · 2026Article
- Comprehensive evaluation of EEG spatial sampling, head modelling and parcellation effects on network alterations in idiopathic generalized epilepsy.Brain communications · 2026Article
- From network hub to therapeutic target: the role of mediodorsal thalamic nucleus in epilepsy.Frontiers in neuroscience · 2026Review
- Brain Network Signature of Autoscopic Phenomena in Humans.CNS neuroscience & therapeutics · 2025Article
- From adaptive deep brain stimulation to adaptive circuit targeting.Nature reviews. Neurology · 2025Review
- Increased volumes of the precuneus and the pallidum in idiopathic generalized epilepsy.Scientific reports · 2025Article
- Biomarkers for Epilepsy Deep Brain Stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Review
- Connectomes in Temporal Lobe and Idiopathic Generalized Epilepsies.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
44 authors.
Gong-Jun Ji *Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui Province, 230032, China.ORCID http://orcid.org/0000-0002-7073-5534
Michael D Fox *Center for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0001-8848-6399
Mae Morton-DuttonCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Yingru WangThe School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China.
Jinmei SunDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui Province, 230032, China.ORCID http://orcid.org/0000-0002-8397-9773
Panpan HuDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Xingui ChenDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Yubao JiangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Chunyan ZhuThe School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China.ORCID http://orcid.org/0000-0002-3434-2581
Yanghua TianDepartment of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230032, China.ORCID http://orcid.org/0000-0001-5038-0599
Zhiqiang ZhangDepartment of Diagnostic Radiology, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China.ORCID http://orcid.org/0000-0002-3993-7330
Haya AkkadCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Janne NordbergNeurocenter, Department of Clinical Neurophysiology, Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0002-2917-4341
Juho JoutsaNeurocenter, Department of Clinical Neurophysiology, Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0002-3457-9415
Cristina V Torres DiazDepartment of Neurourgery, Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Sergiu GroppaMovement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Rhine Main Neuroscience Network (rmn2), Mainz, Germany.ORCID http://orcid.org/0000-0002-2551-5655
Gabriel Gonzalez-EscamillaMovement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Rhine Main Neuroscience Network (rmn2), Mainz, Germany.ORCID http://orcid.org/0000-0002-7209-1736
Maria de ToledoDepartment of Neurology, Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Linda J DalicDepartment of Medicine (Austin Health), The University of Melbourne, Victoria, Australia.
John S ArcherDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0002-3939-3847
Richard SelwayDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Ioannis StavropoulosDepartment of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-6920-1826
Antonio ValentinDepartment of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Jimmy YangDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH, USA.
Faical IsbaineDepartments of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Robert E GrossDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA.
Sihyeong ParkDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6371-265X
Nicholas M GreggDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6151-043X
Arthur CukiertDepartment of Neurosurgery, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-6563-4149
Erik H MiddlebrooksDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Nico U F DosenbachMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6876-7078
Joseph TurnerCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0009-0009-2423-3451
Aaron E L WarrenCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0001-6534-2800
Melissa M J ChuaCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Alexander L CohenCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0001-6557-5866
Sara LarivièreCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Clemens NeudorferCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0002-3153-1045
Andreas HornCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0002-0695-6025
Rani A SarkisCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0001-8291-7864
Ellen J BubrickCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Robert S FisherDepartment of Neurology and Neurological Sciences and Neurosurgery by courtesy, Stanford University School of Medicine, Palo Alto, California, USA.
John D RolstonCenter for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0002-8843-5468
Kai Wang *Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui Province, 230032, China. wangkai1964@126.com.ORCID http://orcid.org/0000-0002-6197-914X
Frederic L W V J Schaper *Center for Brain Circuit Therapeutics, Department of Neurology, Neurosurgery, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. fredericschaper@icloud.com.ORCID http://orcid.org/0000-0001-5487-0923
Funding
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7MAdolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5MBRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5MNIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIDDK NIH HHS U01 DK140734NIMH NIH HHS K23 MH120510NIMH NIH HHS R01 MH113929NINDS NIH HHS R01 NS127892NINDS NIH HHS R01 NS136297NINDS NIH HHS UG3 NS114438NINDS NIH HHS UH3 NS109557NINDS NIH HHS UM1 NS132358
Abstract
Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this network and its relevance for treatment remain unclear. We combine the locations of brain abnormalities in IGE (131 coordinates from 21 studies) with the human connectome to identify an IGE network. We validate this network by showing alignment with structural brain abnormalities previously identified in IGE and brain areas activated by generalized epileptiform discharges in simultaneous electroencephalogram-functional magnetic resonance imaging. The topography of the IGE network aligns with brain networks involved in motor control and loss of consciousness consistent with generalized seizure semiology. To investigate therapeutic relevance, we analyze data from 21 patients with IGE treated with deep brain stimulation (DBS) for generalized seizures. Seizure frequency reduced a median 90% after DBS and stimulation sites intersect an IGE network peak in the centromedian nucleus of the thalamus. Together, this study helps unify prior findings in IGE and identify a brain network target that can be tested in clinical trials of brain stimulation to control generalized seizures.
Indexed as
BrainDeep Brain StimulationEpilepsy, GeneralizedNerve NetAdolescentAdultConnectomeElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSeizuresYoung Adult
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