ArticleThe Journal of comparative neurology2025
Timing Matters: Lessons From Perinatal Neurogenesis in the Olfactory Bulb.
Article in The Journal of comparative neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Olfactory bulb interneurons - The developmental timeline and targeting defined by embryonic neurogenesis.Molecular and cellular neurosciences · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
In the olfactory bulb (OB), odorant receptor-specific input converges into glomeruli. Subsequently, the coding of odor information is fine-tuned by local synaptic circuits within the glomeruli and the deeper external plexiform layer (EPL) in the OB. Deciphering the organization of inhibitory granule cells (GCs) in the EPL relative to the secondary dendrites of projection neurons is pivotal for understanding odor processing. We conducted a detailed investigation of GCs, focusing on the timing of neurogenesis, laminar distribution, and synaptogenesis between GCs and projection neurons. In summary, GCs develop following a developmental continuum with an outside-in maturation pattern from embryogenesis to adulthood. GCs born 1 week after birth display a unique sublayer-specific distribution pattern, marking a transition between embryonic or neonatal and adult stages. Integration into reciprocal synaptic circuits occurred 10 days post-neurogenesis. We conclude that the timing of neurogenesis dictates the anatomical configuration of GCs within the OB, which, in turn, regulates preferential synaptic integration with either mitral cell or tufted cell secondary dendrites.
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