ArticleFEMS microbiology letters2025
Antibiofilm activity of Clitoria ternatea flowers anthocyanin fraction against biofilm-forming oral bacteria.
Article in FEMS microbiology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the antibiofilm effects of Clitoria ternatea flowers anthocyanin fraction (AF) on Streptococcus mutans, Actinomyces viscosus, and Aggregatibacter actinomycetemcomitans. AF was obtained using column chromatography, and liquid chromatography-mass spectrometry was employed for its characterization and identification. The crystal violet assay and scanning electron microscopy analysis revealed significant inhibition of early biofilm formation and destruction of preformed biofilms after AF treatment (0.94-15 mg ml-1). Antiadhesion assay on acrylic teeth demonstrated that AF effectively hampered sucrose dependent and independent attachment. Importantly, growth curve and pH drop assays showed that AF inhibited pH reduction for all bacteria tested without hindering bacterial growth. Furthermore, the tetrazolium-based cytotoxicity assay indicated no toxicity towards normal human gingival fibroblasts at 0.78-12.5 mg ml-1. These findings suggest C. ternatea anthocyanins are promising antibiofilm agents for oral biofilm control, acting during both initial formation and on mature biofilms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.