ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
ACC Reward Location Information Is Carried by Hippocampal Theta Synchrony and Suppressed in a Type 2 Diabetes Model.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Computational Properties of the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Epigenetic Profiling of Cell-Free DNA in Cerebrospinal Fluid: A Novel Biomarker Approach for Metabolic Brain Diseases.Life (Basel, Switzerland) · 2025Review
- Impact of chronic hyperglycemia and high-fat diet on Alzheimer's disease-related pathology in CX3CR1 knockout mice.Metabolic brain disease · 2025Article
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Abstract
The anterior cingulate cortex (ACC) is important for higher-order cognitive functions, emotional responses, and monitoring internal states. ACC dysfunction has been implicated in an array of psychiatric and neurodegenerative disorders which have a bidirectional relationship with the metabolic disorder Type 2 diabetes (T2D). T2D is a chronic disease characterized by hyperglycemia, loss of insulin signaling, neuroinflammation, and increased morbidity and mortality chances. To better understand the functional effects of T2D on ACC information processing, we delivered an intermittent, low-dose streptozotocin (STZ) protocol to rats (all male due to female insensitivity to STZ) which led to lasting hyperglycemia and recorded single neurons during a delayed alternation task. We observed changes in spatial and reward processing in spite of no differences in overall behavioral accuracy, though we did find hyperglycemic animals spent less time at the reward site. Hyperglycemic animal (
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