ArticleThe American journal of clinical nutrition2025
Dietary polyphenols and risk of breast cancer in a predominantly low-income population: a prospective analysis in the Southern Community Cohort Study (SCCS).
Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study.Antioxidants (Basel, Switzerland) · 2026Article
- Dietary Polyphenol Combinations Have a Multifaceted Inhibitory Effect on Metabolic Rewiring and Signaling Pathways in Neuroblastoma.Pharmaceuticals (Basel, Switzerland) · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundFew studies have examined the associations of specific dietary polyphenols with breast cancer (BC) risks or among non-Hispanic Black (NHB) female individuals in the United States.
objectivesWe aim to evaluate the associations between total and subclasses of polyphenol intake and BC risk, stratified by body mass index (BMI), estrogen receptor (ER)/progesterone receptor (PR) status, menopausal status, and racial and ethnic subgroups.
methodsThe study included 42,260 female participants from the Southern Community Cohort Study, a large prospective cohort of predominantly low-income NHB Americans. The dietary polyphenol components were assessed using a validated culturally sensitive 89-item food frequency questionnaire designed specifically for nutrient intakes in the South. Cox proportional hazards model was used to assess the associations after adjustment for confounders including sociodemographic and lifestyle factors.
resultsIntakes of total polyphenols were higher in non-Hispanic white (1122 ± 727 mg/d) than in NHB female individuals (535±349 mg/d). Intakes of total polyphenol, particularly phenolic acids, were associated with reduced risk of BC incidence among female individuals with the ER+ and PR+ BC type comparing the highest to the lowest quintile [hazard ratio (HR) 0.69; 95% confidence interval (CI): 0.51, 0.94; P
conclusionsIn this predominantly low-income United States population, intakes of total polyphenol and phenolic acids were associated with reduced risk of BC among those with ER+ and PR+ BC type, postmenopausal, and female individuals with overweight/obesity.
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