Evidence map›Paper›PMID 40127680›Full record

ArticleNature2025

Generalizing arene C-H alkylations by radical-radical cross-coupling.

Johannes Großkopf, Chawanansaya Gopatta, Robert T Martin, Alexander Haseloer, David W C MacMillan

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. 1,2-Diketones asChemical science · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Site-Selective Distal Arylation of Sugars Enabled by Cyclic Acetals.Journal of the American Chemical Society · 2026
    Article
  7. Article
  8. Piecewise Stereoselective Assembly of Multisubstituted Alkenes.Journal of the American Chemical Society · 2026
    Article
  9. Oxyalkylation of Alkenes via Triple Radical Sorting.Journal of the American Chemical Society · 2026
    Article
  10. Article
  11. Alkoxysulfonium Salts Unlock Access to New Aryl Sulfonium Salts for Cross-Coupling.Angewandte Chemie (International ed. in English) · 2026
    Article
  12. Article
  13. A General Metallaphotoredox Platform forJournal of the American Chemical Society · 2025
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Johannes GroßkopfMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-6540-3893
Chawanansaya GopattaMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.
Robert T MartinMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.
Alexander HaseloerMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-0480-7568
David W C MacMillanMerck Center for Catalysis at Princeton University, Princeton, NJ, USA. dmacmill@princeton.edu.ORCID http://orcid.org/0000-0001-6447-0587

Funding

Photoredox Catalysis Applications in Organometallics and Chemical BiologyR35GM134897 · NIGMS · PRINCETON UNIVERSITY · PI David W MacMillan · 2020 to 2026
$6.3M
NIGMS NIH HHS R35 GM134897
6 · The paper itself

Abstract

The efficient and modular diversification of molecular scaffolds, particularly for the synthesis of diverse molecular libraries, remains a notable challenge in drug optimization campaigns

Identifiers

PMID40127680
PMCPMC12067629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.