Evidence map›Paper›PMID 40127552›Full record

ArticleTalanta2025

Development of a nanobody-based immunoassay for the analysis of the disinfectant triclosan in water.

Bojie Xu, Xiangyu Zhang, Kai Wang, Xianle Xue, Surat Hongsibsong, Christophe Morisseau, Qing X Li, Bruce D Hammock, Ting Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Talanta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bojie XuBeijing Key Laboratory of Biodiversity and Organic Farming, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
Xiangyu ZhangBeijing Key Laboratory of Biodiversity and Organic Farming, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
Kai WangBeijing Key Laboratory of Biodiversity and Organic Farming, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
Xianle XueBeijing Key Laboratory of Biodiversity and Organic Farming, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
Surat HongsibsongResearch Institute for Health Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
Christophe MorisseauDepartment of Entomology and UCD Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Qing X LiDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, 1955 East-West Road, Honolulu, HI, 96822, USA.
Bruce D HammockDepartment of Entomology and UCD Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Ting XuBeijing Key Laboratory of Biodiversity and Organic Farming, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China. Electronic address: xuting@cau.edu.cn.

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443
6 · The paper itself

Abstract

Triclosan (TCS), a broad-spectrum antimicrobial agent in pharmaceuticals and personal care products, necessitates environmental monitoring due to its antimicrobial properties and widespread in the environment. In this study, two anti-TCS single-domain antibodies (i.e., nanobodies, Nbs), T1 and T2, were isolated from a phage-displayed Nb library derived from a camel immunized with a mixture of TCS immunogens. The T1-based enzyme-linked immunosorbent assay (ELISA) exhibited a better sensitivity to TCS than the T2-base ELISA. Motivation at enhancing specificity, sensitivity, and stability of Nb-based immunoassays promoted exploring use of a bivalent strategy to enhance performance. The bivalent Nb T1-T1 was tandemized via a linker-(GGGGS)3- between. The thermal stability of the bivalent Nb was improved in comparison with that of a monovalent Nb. The sensitivity of T1-T1-based ELISA, with an IC

Indexed as

DisinfectantsSingle-Domain AntibodiesTriclosanWater Pollutants, ChemicalAnimalsCamelusEnzyme-Linked Immunosorbent AssayDisinfectantsSingle-Domain AntibodiesTriclosanWater Pollutants, ChemicalBivalentELISAImmunoassayNanobodyTriclosanWater

Identifiers

PMID40127552
PMCPMC12018125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.