Evidence map›Paper›PMID 40127501›Full record

ArticleClinical and experimental otorhinolaryngology2025

Vestibular Aqueduct and Temporal Bone Radioanatomy in Patients With and Without Meniere Disease: A Retrospective Cross-Sectional Analysis With Implications for Endolymphatic Sac Surgery.

Jeanne Bernard, Dario Ebode, Priya Vishnumurthy, Antonino Maniaci, Maria-Pia Tuset, Mario Lentini, Ralph Haddad, Giannicola Iannella, Mary Daval, Justin Michel and 1 more

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Article in Clinical and experimental otorhinolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jeanne BernardDepartment of Otorhinolaryngology-Head and Neck Surgery, La Conception University Hospital, APHM, Aix Marseille University, Marseille, France.
Dario EbodeDepartment of Otorhinolaryngology-Head and Neck Surgery, La Conception University Hospital, IUSTI, CNRS, APHM, Aix Marseille University, Marseille, France.
Priya VishnumurthyDepartment of Otorhinolaryngology-Head and Neck Surgery, La Conception University Hospital, IUSTI, CNRS, APHM, Aix Marseille University, Marseille, France.
Antonino ManiaciDepartment of Otolaryngology, Enna Kore University, Enna, Italy; YO-IFOS Otology Study Group.
Maria-Pia TusetDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Foundation Adolphe de Rothschild, Paris, France.
Mario LentiniDepartment of Otolaryngology, Enna Kore University, Enna, Italy; YO-IFOS Otology Study Group.
Ralph HaddadDepartment of Otorhinolaryngology-Head and Neck Surgery, La Conception University Hospital, IUSTI, CNRS, APHM, Aix Marseille University, Marseille, France.
Giannicola IannellaDepartment of Sensory Organs, Sapienza University of Rome, Rome, Italy; YO-IFOS Otology Study Group.
Mary DavalDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Foundation Adolphe de Rothschild, Paris, France.
Justin MichelDepartment of Otorhinolaryngology-Head and Neck Surgery, La Conception University Hospital, IUSTI, CNRS, APHM, Aix Marseille University, Marseille, France.
Stéphane GargulaDepartment of Otorhinolaryngology-Head and Neck Surgery, La Conception University Hospital, IUSTI, CNRS, APHM, Aix Marseille University, Marseille, France; YO-IFOS Otology Study Group.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe vestibular aqueduct (VA) exhibits significant anatomical variability. These variations and their spatial relationships with neighboring structures may pose technical challenges during endolymphatic sac surgery. We aimed to characterize the anatomical features of the VA and its relationship with surrounding structures in patients with severe Meniere disease compared to controls using high-resolution computed tomography (CT).

methodsThis retrospective study included 65 patients (126 ears) who underwent temporal bone CT. The Meniere group comprised 26 patients (26 affected ears) meeting the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) criteria for intractable disease; the contralateral ear group included 24 ears, and the control group comprised 39 patients (76 ears) with unrelated conditions. Measurements included VA thickness (A), width (B/B´), the distance between the posterior semicircular canal (PSCC) and posterior fossa (C), PSCC depth (D/D´), and operculum depth (E/E´). Correlations were analyzed, and k-means clustering was applied to classify anatomical variations. Reliability was assessed using intra- and inter-observer tests.

resultsVA width (B) correlated positively with the PSCC-meningeal distance (C) (r=0.683, P<0.001) and negatively with PSCC depth (D´) (r=-0.290, P<0.01) and operculum depth (E´) (r=-0.520, P<0.001). Patients with a narrower VA exhibited a reduced PSCC-meningeal distance and a deeper operculum position. The Meniere group demonstrated significantly narrower VA and shorter PSCC-dura distances compared to controls (P<0.001). Cluster analysis identified three anatomical patterns, with 61.5% of intractable Meniere ears versus 14.5% of controls and 41.6% of contralateral ears falling into the cluster characterized by smaller VA dimensions, shorter PSCC-dura distances, and deeper operculum positions.

conclusionA narrow VA correlates with a reduced PSCC-meningeal distance and a deeper operculum position, potentially complicating endolymphatic sac surgery. These anatomical variations are more prevalent in patients with severe Meniere disease, highlighting the need for tailored surgical approaches.

Indexed as

AnatomyEndolymphatic DuctEndolymphatic SacMeniere DiseaseSurgeryTemporal Bone Computed TomographyVestibular Aqueduct

Identifiers

PMID40127501
PMCPMC12146606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.