ArticleNeurology2025
Association of Cardiovascular Health With Brain Volume and White Matter Integrity: Results of the SOL-INCA MRI Study.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Lifetime Cannabis Use Is Associated With Brain Volume and Cognitive Function in Middle-Aged and Older Adults.Journal of studies on alcohol and drugs · 2026Article
- No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults.Frontiers in aging neuroscience · 2026Article
- Disentangling the contributions of cerebrovascular-related white matter integrity markers to cognitive aging.Cerebral circulation - cognition and behavior · 2025Article
- Life's Essential 8 and cerebrovascular disease among Hispanic/Latino adults: findings from the Hispanic Community Health Study/Study of Latinos and Study of Latinos-Investigation of Neurocognitive Aging magnetic resonance imaging cohort.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
16 authors.
Funding
Abstract
BACKGROUND AND
objectivesBetter cardiovascular health (CVH), measured using the Life's Simple 7 (LS7) score, is associated with improved cognitive function. However, its effect on brain imaging in Hispanics/Latinos has not been reported. We investigated the association of LS7 score with brain MRI outcomes in a diverse Hispanic/Latino population.
methodsHispanic Community Health Study/Study of Latinos (HCHS/SOL) is the largest prospective cohort study of diverse Hispanic/Latino adults in the United States. LS7 score was assessed at baseline (2008-2011). The SOL-Investigation of Neurocognitive Aging (SOL-INCA) MRI ancillary study recruited HCHS/SOL participants who underwent neuroimaging approximately 10 years (2017-2022) later. Main outcomes include standardized residuals for total brain, total and lobar gray matter (frontal, temporal, parietal, and occipital), total white matter, total CSF, lateral ventricle (LV), and white matter hyperintensity (WMH) volumes and diffusion tensor imaging (mean free water fraction, peak width skeletonized mean diffusivity, and mean fractional anisotropy). MRI outcomes across continuous LS7 scores were investigated using adjusted linear regression models. We performed an interaction analysis by age and sex. All analyses accounted for complex sample design.
resultsThe study included 2,659 participants (weighted %female = 56%). The mean age (95% CI) was 54 (53-55) years, and the mean LS7 score was 7.2 (7.1-7.3). In the fully adjusted model, higher LS7 scores were associated with larger total and lobar brain volumes (β DISCUSSION: We found that better CVH is associated with better brain-based volumes and microstructural integrity and that the effects of LS7 score on brain health are age dependent. Additional studies are needed to assess the longitudinal effect of CVH on MR-based brain health outcomes.
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