Evidence map›Paper›PMID 40127300›Full record

ArticleEnvironmental health perspectives2025

Improving Methodologies for Cumulative Risk Assessment: A Case Study of Noncarcinogenic Health Risks from Volatile Organic Compounds in Fenceline Communities in Southeastern Pennsylvania.

Andrea A Chiger, Carolyn Gigot, Ellis S Robinson, Mina W Tehrani, Megan Claflin, Edward Fortner, Harald Stark, Jordan Krechmer, Manjula R Canagaratna, Scott Herndon and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andrea A ChigerDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-8865-8573
Carolyn GigotDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Ellis S RobinsonDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Mina W TehraniDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Megan ClaflinAerodyne Research Inc., Billerica, Massachusetts, USA.
Edward FortnerAerodyne Research Inc., Billerica, Massachusetts, USA.
Harald StarkAerodyne Research Inc., Billerica, Massachusetts, USA.ORCID 0000-0002-0731-1202
Jordan KrechmerAerodyne Research Inc., Billerica, Massachusetts, USA.
Manjula R CanagaratnaAerodyne Research Inc., Billerica, Massachusetts, USA.ORCID 0000-0002-8803-4007
Scott HerndonAerodyne Research Inc., Billerica, Massachusetts, USA.
Tara I YacovitchAerodyne Research Inc., Billerica, Massachusetts, USA.
Kirsten KoehlerDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Ana M RuleDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Thomas A BurkeDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Mary A FoxDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Peter F DeCarloDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Keeve E NachmanDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
NIEHS NIH HHS T32 ES007141NIOSH CDC HHS T42 OH008428
6 · The paper itself

Abstract

backgroundCumulative risk assessment (CRA) is key to characterizing health risks in fenceline and disadvantaged communities, which face environmental pollution and challenging socioeconomic conditions. Traditional approaches for inclusion of mixtures in CRA are limited and only assess the most sensitive target organ system for each chemical.

methodsWe developed an expanded approach to cumulative risk assessment that considers all known target organ systems associated with a chemical. Specifically, we created a multi-effects toxicity database by

resultsOf the 32 chemicals quantified in SEPA HAP-MAP, 28 were represented in our multi-effects toxicity database, whereas only 16 were included using a traditional approach. In total, we derived toxicity values for 172 chemical-target organ system combinations. Our expanded approach found neurological, renal, respiratory, endocrine, and systemic risks (hazard index

conclusionOur results suggest that traditional approaches to CRA underestimate health risks in fenceline and other highly exposed communities and highlight the need for improved methods to inform health-protective and just risk management decisions. https://doi.org/10.1289/EHP14696.

Indexed as

Air PollutantsEnvironmental ExposureEnvironmental MonitoringVolatile Organic CompoundsHumansPennsylvaniaRisk AssessmentAir PollutantsVolatile Organic Compounds

Identifiers

PMID40127300
PMCPMC12061051

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.