Evidence map›Paper›PMID 40127140›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Rapid Water Permeation by Aramid Foldamer Nanochannels With Hydrophobic Interiors.

Saquib Farooq, Javid Ahmad Malla, Miroslava Nedyalkova, Rafael V M Freire, Indradip Mandal, Aurelien Crochet, Stefan Salentinig, Marco Lattuada, Charlie T McTernan, Andreas F M Kilbinger

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saquib FarooqDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.
Javid Ahmad MallaArtificial Molecular Machinery Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Miroslava NedyalkovaDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.
Rafael V M FreireDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.
Indradip MandalDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.
Aurelien CrochetDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.
Stefan SalentinigDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.
Marco LattuadaDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.
Charlie T McTernanArtificial Molecular Machinery Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Andreas F M KilbingerDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, CH-1700, Switzerland.

Funding

Cancer Research UK CC2213Medical Research Council CC2213NCCR Bio-Inspired MaterialsSwiss National Science FoundationUKRI under Future Leaders Fellowship MR/W00657X/1Wellcome Trust CC2213
6 · The paper itself

Abstract

Aquaporins are natural proteins that rapidly transport water across cell membranes, maintaining homeostasis, whilst strictly excluding salt. This has inspired their use in water purification and desalination, a critical emerging need. However, stability, scalability, and cost have prevented their widespread adoption in water purification membrane technologies. As such, attention has turned to the use of artificial water channels, with pore-functionalized polymers and macrocycles providing a powerful alternative. Whilst impressive rates of transport have been achieved, the combination of a scalable, high-yielding synthesis and efficient transport has not yet been reported. Herein, we report such a system, with densely functionalized channel interiors, synthesized by high-yielding living polymerization with low polydispersities, showing high salt exclusion and excellent water transport rates. Our aramid foldamers create artificial water channels with hydrophobic interiors and single-channel water permeability rates of up to 10

Indexed as

AquaporinsNanostructuresWaterHydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationPermeabilityAquaporinsWaterAramidsFoldamersHelical polymersIon selectivityMacrocyclesWater transport

Identifiers

PMID40127140
PMCPMC7617624

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.