Evidence map›Paper›PMID 40127114›Full record

ArticleInorganic chemistry2025

LnDOTA Releasing Probes for Luminescence and Magnetic Resonance Imaging.

Ceri A Foster, Deborah Sneddon, Lina Hacker, Euan T Sarson, Max Robertson, Daria Sokolova, Louise A W Martin, Matthew F Allen, Alexandr Khrapichev, Kylie A Vincent and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Lanthanide Nanotheranostics in Radiotherapy.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ceri A FosterDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0000-0002-3812-0919
Deborah SneddonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
Lina HackerDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DA, United Kingdom.
Euan T SarsonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0009-0008-5023-3570
Max RobertsonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0009-0004-6949-3998
Daria SokolovaDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
Louise A W MartinDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DA, United Kingdom.
Matthew F AllenDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0000-0003-2041-246X
Alexandr KhrapichevDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DA, United Kingdom.
Kylie A VincentDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0000-0001-6444-9382
Ester M HammondDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DA, United Kingdom.ORCID 0000-0002-2335-3146
Stuart J ConwayDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0000-0002-5148-117X
Stephen FaulknerDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0000-0003-1878-5857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lanthanide complexes of DOTA monoesters bearing nitrobenzyl and nitroimidazole groups are shown to be converted to the corresponding DOTA complexes under chemical and enzymatic conditions, giving rise to favorable changes in the luminescence properties of the europium and terbium complexes and relaxometric properties of the gadolinium complexes. The nitroimidazole complexes are converted more rapidly than their nitrobenzyl and benzyl analogues. We propose that activation of these complexes may occur by ester cleavage rather than nitro reduction and fragmentation since complexes bearing a simple benzyl group may also be cleaved under the same conditions, albeit more slowly.

Identifiers

PMID40127114
PMCPMC11979886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.