Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Tiago J CostaCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.ORCID 0000-0003-0780-4290
Milene T FontesCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.ORCID 0000-0003-4325-5153
Paula R BarrosCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.ORCID 0000-0001-5428-8490
Marion C HopeDepartment of Pathology, Microbiology, & Immunology, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.ORCID 0000-0002-4855-5764
R Clinton WebbCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.
Camilla F WenceslauCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.ORCID 0000-0002-0815-3568
Reilly T EnosDepartment of Pathology, Microbiology, & Immunology, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.ORCID 0000-0001-5571-4586
Cameron G McCarthyCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, United States.ORCID 0000-0002-1380-779X
Funding
Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
Targeting early ceramide elevation in pre-symptomatic eczemaP20GM103641 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ENOS, REILLY, NAGARKATTI, PRAKASH S · 2012 to 2023
$20.7M
LRRC8 anion channels, superoxide and RhoA in diabetic erectile dysfunctionR01DK132948 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LAMB, FRED S, WEBB, R CLINTON · 2022 to 2025
$2.7M
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertensionR01HL149762 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2021 to 2025
$1.9M
8-Prenylnaringenin: A Natural Therapy for Estrogen DeficiencyK01AT010348 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ENOS, REILLY · 2020 to 2024
$859k
Autophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular agingR00HL151889 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCCARTHY, CAMERON · 2022 to 2024
$742k
American Heart Association (AHA) 916031HHS | National Institutes of Health (NIH) K01AT010348HHS | National Institutes of Health (NIH) P20GM103641HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R00HL151889HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01DK132948HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL149762NCCIH NIH HHS K01 AT010348NHLBI NIH HHS R00 HL151889NHLBI NIH HHS R01 HL149762NIDDK NIH HHS R01 DK132948NIGMS NIH HHS P20 GM103641NIGMS NIH HHS P20 GM109091USC | Office of the Vice President for Research, University of South Carolina 180950-23-64136USC | Office of the Vice President for Research, University of South Carolina ASPIRE Award 64136
6 · The paper itself
Abstract
Menopause has unequivocally been associated with cardiovascular risk and obesity. Loss of estrogen bioavailability is a hallmark of menopause. Estrogen is generally considered vasculoprotective, with estrogen receptor α (ERα) being the predominant receptor subtype that mediates these positive effects. Similarly, estrogen and ERα are known to stimulate white adipose tissue metabolism. However, it is unknown whether ERα could exert a beneficial effect on mesenteric perivascular adipose tissue (PVAT). PVAT is a heterogeneous tissue that surrounds most peripheral blood vessels. In physiological conditions, PVAT has an anticontractile effect on the vasculature. However, in several diseases, PVAT switches its phenotype to become procontractile. To date, the role of ERα in PVAT function in health and disease is unknown. Therefore, we hypothesized that overexpression of adipose tissue ERα (ERα
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Overexpression of adipose tissue ERα enhances PVAT anticontractility via NOX4-derived H · full record | OpenQuestion