ArticleNeuro-oncology2025
Differentiation of tumor versus peritumoral cortex in gliomas by intraoperative electrocorticography.
Article in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Early High-Frequency Network Reorganization After Spinal Cord Stimulation Is Linked to Long-Term Recovery in Disorders of Consciousness.CNS neuroscience & therapeutics · 2026Article
- A novel strategy for the photothermal treatment and electroencephalogram monitoring ofRSC advances · 2026Article
- Increased neural excitability and glioma synaptic activity drives glioma proliferation in human cortex.Nature neuroscience · 2026Article
- Mapping glioma electromagnetic waves and temperature as a surgical strategy to resect a diffusely infiltrative glioma.Surgical neurology international · 2026Article
- NeuroDepth: an ultra long whole brain reachable multi-channel probe for real-time precise functional localization of deep human brain tumor margins.Microsystems & nanoengineering · 2025Article
- Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation.bioRxiv : the preprint server for biology · 2025Article
- Electrophysiology of gliomas: current science, implications, and opportunities.Frontiers in oncology · 2025Review
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18 authors.
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Abstract
backgroundBrain diffuse gliomas are highly epileptic and infiltrative tumors. Glioma surgery consists of the resection of the tumor core and the maximum of the peritumoral zone, infiltrated by tumor cells, guided by the intraoperative assessment of brain functionality and connectivity. However, its electrophysiological characteristics are poorly characterized.
methodsWe studied the characteristics of electrocorticographic (ECoG) signals, in the context of glioma surgery in awake conditions on 29 patients, using EEG activity sampled on the tumor itself versus on its borders and in healthy areas. We assessed the features of frequency bands and aperiodic components (offset and slope) of ECoG power spectra during awake glioma surgery, according to cortical tumoral versus peritumoral and healthy status.
resultsWe found that tumor contacts present a decrease in activity for all the frequency bands except for delta activity, which was increased. Second, the peritumoral cortex was characterized by an increase in relative beta activity and slopes between 20 and 40 Hz. Low cortical tumor cell infiltration was directly correlated with a reduction in the production of physiological brain rhythms. Finally, an automatic classifier based on neural networks allowed the classification of the electrodes based on their power spectrum characteristics.
conclusionsThis intraoperative study shows that ECoG during glioma surgery in awake condition may characterize the peritumoral cortices, key for pathophysiology and therapy, and deepens our knowledge of the effects of tumor cell infiltration on nervous tissue activity. Its assessment during the surgical procedure should better delineation of the cortical areas to be removed.
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