Evidence map›Paper›PMID 40126903›Full record

ArticleJournal of cellular and molecular medicine2025

Cardiac FGF23 Increases Intracellular Calcium in Atrial Myocytes and the Susceptibility to Atrial Fibrillation Decreased in FGF23

Xiao-Qian Li, Mei-Qiong Wu, Li-Hua Fang, Qian Chen, Zhi-Jie Chen, Zhu-Hui Lin, Jian-Quan Chen, Panashe Makota, Yang Li, Jian-Cheng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Comprehensive assessment of novel cardiovascular biomarkers in AF.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiao-Qian LiShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.
Mei-Qiong WuShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.
Li-Hua FangDepartment of Cardiovascular Medicine, Fuzhou First Hospital Affiliated With Fujian Medical University, Fuzhou, Fujian, China.
Qian ChenShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.ORCID 0000-0002-9581-8002
Zhi-Jie ChenShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.
Zhu-Hui LinShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.
Jian-Quan ChenShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.
Panashe MakotaShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.
Yang LiDepartment of Cardiology, The Sixth Medical Center, Chinese People's Liberation Army Hospital, Beijing, China.
Jian-Cheng ZhangShengli Clinical Medicine College of Fujian Medical University, Fuzhou, Fujian, China.

Funding

Fujian Province Science and Technology Innovation Joint Fund Project 2023Y9350National Natural Science Foundation of China 82070341Natural Science Foundation of Fujian Province 2023J011189
6 · The paper itself

Abstract

Exogenous fibroblast growth factor (FGF) 23 is closely associated with atrial fibrillation (AF) and is able to alter the cardiac electrophysiological activity by increasing intracellular calcium. While its arrhythmogenic mechanism remains unclear, this study aims to investigate the electrophysiological effects of cardiac FGF23 on intracellular calcium in atrial cells and its underlying mechanism. The incidence of AF was significantly decreased in FGF23

Indexed as

Atrial FibrillationCalciumFibroblast Growth FactorsHeart AtriaMyocytes, CardiacAnimalsCalcium Channels, L-TypeDisease SusceptibilityFibroblast Growth Factor-23MaleMiceRyanodine Receptor Calcium Release ChannelSodium-Calcium ExchangerCalciumCalcium Channels, L-TypeFgf23 protein, mouseFibroblast Growth Factor-23Fibroblast Growth Factorsryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelSodium-Calcium Exchangeratrial fibrillationFGF23intracellular calciumRyR2

Identifiers

PMID40126903
PMCPMC11932160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.