Observational studyIndian pediatrics2025
Hyponatremia in Acute Encephalitis Syndrome (AES) in Children: A Prospective Study From a Tertiary Centre in Northern India.
Observational study in Indian pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hyponatremia upon PICU admission: a 10-year retrospective analysis of outcomes and independent prognostic value.BMC pediatrics · 2026Observational
- Prevalence of Electrolyte Abnormality and its Correlation with Clinical Features and Patient Outcomes in Children Admitted to Pediatric Intensive Care Unit of a Resource-Constrained Setting in India.SAGE open medicine · 2025Article
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Authors and funding
3 authors.
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Abstract
objectiveTo compare the clinical and biochemical parameters and outcomes in children with acute encephalitis syndrome (AES) with and without hyponatremia.
methodsA prospective observational study conducted at a tertiary care teaching hospital included children aged 6 months to 12 years with AES defined as acute fever (< 7 days) and neurological symptoms such as new-onset seizures or altered mental status lasting more than 12 h. AES was categorized as neurological or systemic AES. Serum electrolyte samples were collected upon admission and daily for three days to assess the occurrence of hyponatremia (serum sodium < 135 mmol/L). Outcomes were assessed one-month after discharge using the Pediatric Modified Rankin Scale (mRS).
resultsOut of 200 children with AES, 49 (24.5%) had hyponatremia. Hyponatremia was significantly associated with hepatomegaly (P = 0.002), elevated blood urea (P = 0.033), elevated serum creatinine (P = 0.038), decreased serum albumin (P = 0.013) and decreased serum calcium (P = 0.002). Children with hyponatremia experienced significantly greater mortality (P = 0.020) and a longer hospital stay (P = 0.047). Multivariate analysis revealed significant associations between hyponatremia and hepatomegaly (OR 2.22) and mortality (OR 3.17). Hyponatremia and poor outcomes were more common in children with neurological AES compared to systemic AES syndrome.
conclusionHyponatremia was found in one-fourth of cases of AES and had a significant association with mortality and longer hospital stay.
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