Evidence map›Paper›PMID 40126768›Full record

ArticleMaternal and child health journal2025

Evaluating Associations Among Maternal ACEs, Perinatal Depression, and Infant Experiences of Adversity.

Samantha Addante, Lucia Ciciolla, Amanda Baraldi, Karina M Shreffler

Abstract read
In one paragraph

Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samantha AddanteRUSH University Medical Center, Chicago, USA.
Lucia CiciollaDepartment of Psychology, Oklahoma State University, Stillwater, USA.
Amanda BaraldiDepartment of Psychology, Oklahoma State University, Stillwater, USA.
Karina M ShrefflerFran and Earl Ziegler College of Nursing, University of Oklahoma Health Sciences Center, Oklahoma City, USA. karina-shreffler@ouhsc.edu.ORCID http://orcid.org/0000-0003-0475-5817

Funding

The Impact of Maternal Adversity and Attachment Security on Infant Stress Reactivity: Prenatal Epigenetic PathwaysP20GM109097 · NIGMS · OSU CENTER FOR HEALTH SCIENCES · PI Dian Yu · 2016 to 2026
$22.8M
Training and DevelopmentU54HD113173 · NICHD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI JACOB E FRIEDMAN, PAUL G SPICER · 2023 to 2026
$9.2M
J. NRSA Training CoreTL1TR002388 · NCATS · UNIVERSITY OF CHICAGO · PI ALI KESHAVARZIAN, Sonia Kupfer · 2017 to 2026
$6.7M
FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trialR01CA287257 · NCI · UNIVERSITY OF CHICAGO · PI Fay Kastrinos, Sonia Kupfer · 2024 to 2026
$3.4M
NCATS NIH HHS TL1 TR002388NCI NIH HHS R01 CA287257NICHD NIH HHS U54 HD113173NIGMS NIH HHS P20 GM109097NIGMS NIH HHS P20GM109097
6 · The paper itself

Abstract

objectiveThe growing literature on the intergenerational transmission of childhood adversity highlights the need to identify potential mechanisms underlying the relationship between maternal and infant adversity. This study examines prenatal and postpartum depressive symptoms as mediators between maternal ACEs and postpartum infant experiences of adversity.

methodsA diverse sample of 168 low-income, pregnant women (39% white) were recruited from urban prenatal clinics and followed for one-year post childbirth. Maternal childhood adversity and prenatal depressive symptoms were assessed during pregnancy, postpartum depressive symptoms were assessed at 6 months postpartum, and infant experiences of adversity at 12 months postpartum.

resultsThe total indirect effect of maternal ACEs on infant experiences of adversity through prenatal and postpartum depressive symptoms was significant, indicating that these symptoms collectively mediate this relationship. Additionally, our results demonstrated a mediated pathway in which maternal ACEs contributed directly to prenatal depression, which in turn indirectly influenced postpartum depression and infant experiences of adversity.

conclusionFindings provide evidence for perinatal depressive symptoms as a potential mechanism that influences infant exposure to adverse experiences. Future research should explore these pathways in larger, more robust samples to clarify the role of postpartum depressive symptoms.

Indexed as

Adverse Childhood ExperiencesDepressionDepression, PostpartumMothersPregnant PeopleAdultFemaleHumansInfantPostpartum PeriodPovertyPregnancyAdversityDepressionInfancyPostpartumPregnancy

Identifiers

PMID40126768
PMCPMC12124230

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.