ArticleEuropean radiology experimental2025
Reducing contrast media and radiation dose in CT angiography at low tube voltage: animal study with photon-counting detector CT.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Endoleak detection with photon-counting detector CT at various radiation doses after endovascular aneurysm repair: a phantom study.The international journal of cardiovascular imaging · 2026Article
- Dual-energy CT pulmonary angiography using dual-flow mixture bolus tracking: potential for contrast medium and radiation exposure reduction.Insights into imaging · 2026Article
- Photon-counting CT in neuroradiology: a comprehensive SWOT analysis.European radiology · 2026Review
- Contrast media and radiation dose optimization with task-based automatic keV selection: a proof-of-concept study with photon-counting detector CT.European radiology · 2025Article
- Study on the effect of three-low technique in aortic computed tomography angiography for patients with body mass index <30 kg/mQuantitative imaging in medicine and surgery · 2025Article
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Authors and funding
9 authors.
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Abstract
backgroundReducing radiation and contrast media (CM) doses in computed tomography angiography (CTA) is especially relevant for potentially vulnerable populations. Low tube voltage photon-counting detector CT (PCD-CT) offers an improved iodine contrast-to-noise ratio (CNR) as compared to conventional CT scanners. We investigated optimized radiation and CM doses of PCD-CT angiography at low tube voltage in an animal model.
methodsSix minipigs (median weight: 32.5 kg; IQR: 29.8-34.6 kg) underwent thoracoabdominal CTA using a clinical dual-source PCD-CT at 70 kVp with three scan protocols: (A) reference (100% CM and radiation dose), (B) increased radiation (233%) and reduced CM (56%) dose, and (C) reduced radiation (50%) and increased CM (141%) dose. CNR, subjective image quality, and radiation doses were assessed, with statistical analysis including Mann-Whitney U-test and Kruskal-Wallis tests.
resultsCTDI
conclusionLow tube voltage PCD-CT angiography allows substantial reductions in radiation and CM dose while maintaining stable and improved CNR, which allows further dose flexibility for individualized CTA protocols. RELEVANCE STATEMENT: PCD-CT at low tube voltage provides a high CNR and great flexibility in dose optimization, making it particularly effective for applications where minimizing radiation and CM exposure is a priority. KEY POINTS: Low tube voltage imaging with photon counting detector (PCD)-CT enables flexible contrast and radiation dose optimization strategies in thoracoabdominal CT angiography (CTA). The CNR for thoracoabdominal CTA remains stable with appropriate contrast and radiation dose adjustments at low tube voltage PCD-CT. Low tube voltage PCD-CT consistently yields diagnostic image quality in thoracoabdominal angiography even at reduced contrast or radiation doses.
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