Evidence map›Paper›PMID 40126736›Full record

ArticleJournal of patient-reported outcomes2025

A new generation of patient-reported outcome measures with large language models.

Jan Henrik Terheyden, Maren Pielka, Tobias Schneider, Frank G Holz, Rafet Sifa

Abstract read
In one paragraph

Article in Journal of patient-reported outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Patient-reported outcome measures in lumbar disc herniation: a scoping review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jan Henrik TerheydenUniversity Hospital Bonn, Department of Ophthalmology, Venusberg-Campus 1, 53127, Bonn, Germany. jan.terheyden@ukbonn.de.ORCID http://orcid.org/0000-0002-0174-4066
Maren PielkaBonn-Aachen International Center for Information Technology, University of Bonn, Friedrich- Hirzebruch-Allee 6, 53115, Bonn, Germany.
Tobias SchneiderBonn-Aachen International Center for Information Technology, University of Bonn, Friedrich- Hirzebruch-Allee 6, 53115, Bonn, Germany.
Frank G HolzUniversity Hospital Bonn, Department of Ophthalmology, Venusberg-Campus 1, 53127, Bonn, Germany.
Rafet SifaBonn-Aachen International Center for Information Technology, University of Bonn, Friedrich- Hirzebruch-Allee 6, 53115, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatient-reported outcome measures (PROMs) are cornerstones of patient-centered clinical medicine and reflect patients' abilities, difficulties, perceptions and behaviors. The highly structured questionnaire format of PROMs currently limits their real-world validity and acceptability to patients, which becomes increasingly relevant with the high clinical interest in PROM data. In this short commentary, we aim to demonstrate the potential use of large language models (LLMs) in the context of PROM data collection and interpretation. MAIN BODY: The popularization of LLMs enables the development of a new generation of PROMs generated and administered through digital technology that interact with patients and score their responses in real time based on artificial intelligence. LLM-PROMs will need to be developed with multi-stakeholder input and careful validation against established PROMs. LLM-PROMs could complement traditional PROMs particularly in real-world clinical applications.

conclusionLLM-PROMs could allow quantifying patient-relevant dimensions based on less structured contents and foster the use of patient-reported data in digital, clinical applications of PROMs.

Indexed as

Patient Reported Outcome MeasuresArtificial IntelligenceHumansLarge Language ModelsSurveys and QuestionnairesDigital medicineGenerative artificial intelligenceLarge Language modelsPatient-reported outcome measures

Identifiers

PMID40126736
PMCPMC11933620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.