Evidence map›Paper›PMID 40126353›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Single-Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence.

Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li and 6 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yubin XieInstitute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 518000, P. R. China.
Chen ChenInstitute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 518000, P. R. China.
Fei WuDepartment of Sports Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, P. R. China.
Yiman PengDepartment of Sports Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, P. R. China.
Jing SuDepartment of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, P. R. China.
Yang ZhaoDepartment of Laboratory Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, P. R. China.
Hongjie HuangDepartment of Sports Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, P. R. China.
Zhong Alan LiDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China.
Yin PeiDepartment of Sports Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, P. R. China.
Wencui LiHand and Foot Surgery Department, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, 518035, P. R. China.
Yi HeEmergency Trauma Center, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510700, P. R. China.
Tianchen XueDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 518000, P. R. China.
Chenxi CaoDepartment of Sports Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, P. R. China.
Sui PengInstitute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 518000, P. R. China.
Xin ZhangDepartment of Sports Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, P. R. China.
Weidong SongTrauma Orthopedics, Foot and Ankle Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiangxi Road, Guangzhou, Guangdong, 510120, P. R. China.ORCID https://orcid.org/0000-0001-8638-4874

Funding

Beijing Science and Technology Nova Cross Program 20220484180National Key Research and Development Program of China 2023YFC2705900National Natural Science Foundation of China 82172447National Natural Science Foundation of China 82302746Science and Technology Program of Guangzhou 202201020365Sun Yat-Sen Memorial Hospital Clinical Research 5010 Program SYS-5010-202403
6 · The paper itself

Abstract

Diffuse-type tenosynovial giant cell tumor (D-TGCT) and localized-type tenosynovial giant cell tumor (L-TGCT) share common genomic aberrations and histopathological features, but the former has a more aggressive nature and a higher recurrence rate, leading to worse prognoses for patients. In this study, single-cell RNA sequencing (scRNA-seq) on human D-TGCT and L-TGCT lesions is conducted to discover transcriptional differences. A unique cluster of tumor cells in D-TGCT is identified that regulated differentiation of CD34

Indexed as

Biomarkers, TumorGiant Cell Tumor of Tendon SheathNeoplasm Recurrence, LocalSingle-Cell AnalysisFemaleFibroblastsHumansMaleMiddle AgedBiomarkers, Tumorlocal aggressionrecurrencesingle‐cell RNA sequencingtenosynovial giant cell tumors

Identifiers

PMID40126353
PMCPMC12244509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.