Evidence map›Paper›PMID 40126236›Full record

ArticlePediatric reports2025

Influence of the Timing of Gender Dysphoria Presentation and Suicidal Behaviors on Internalizing Symptoms, Emotion Dysregulation, and Body Investment in Adolescents Seeking Gender Affirmation.

Maria Giuseppina Petruzzelli, Federica Annecchini, Flora Furente, Fabio Tarantino, Valeria Carruolo, Elisabetta Lavorato, Maria Pia Riccio, Andrea De Giacomo, Emilia Matera

Abstract read
In one paragraph

Article in Pediatric reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria Giuseppina PetruzzelliTranslational Biomedicine and Neuroscience Department (DiBraiN), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-1734-788X
Federica AnnecchiniTranslational Biomedicine and Neuroscience Department (DiBraiN), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0009-0009-2713-3202
Flora FurenteTranslational Biomedicine and Neuroscience Department (DiBraiN), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-7081-2520
Fabio TarantinoTranslational Biomedicine and Neuroscience Department (DiBraiN), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0009-0000-0164-5239
Valeria CarruoloTranslational Biomedicine and Neuroscience Department (DiBraiN), University of Bari "Aldo Moro", 70124 Bari, Italy.
Elisabetta LavoratoPsychiatry Unit, Azienda Ospedaliero-Universitaria Policlinico di Bari, University of Bari "Aldo Moro", 70100 Bari, Italy.
Maria Pia RiccioDepartment of Medical and Translational Sciences, Child Neuropsychiatry, Federico II University, Corso Umberto I 40, 80138 Napoli, Italy.ORCID 0000-0002-9311-9099
Andrea De GiacomoTranslational Biomedicine and Neuroscience Department (DiBraiN), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-3454-1679
Emilia MateraDepartment of Regenerative and Precision Medicine and Jonic Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-7541-0616

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have consistently shown that gender-diverse youth experience higher rates of internalizing disorders and self-harm behaviors (SH) compared to their cisgender peers. However, there is limited research on how body investment and emotion regulation influence these symptoms, especially in relation to the age of gender dysphoria (GD) presentation.

objectivesThis study aimed to explore the relationship between the timing of GD presentation (early vs. late) and psychological distress in adolescents seeking gender affirmation (GA), specifically focusing on internalizing symptoms, emotion regulation, and body investment. The study also investigated how SH during the year preceding the request for gender affirmation might have impacted these factors.

methodsOn a total of 80 adolescents (mean age: 14.88 years) at their first request for GA, participants were divided into two groups: early-presentation GD (EP-GD; mean age: 14.93 years) and late-presentation GD (LP-GD; mean age: 14.83 years). Among the sample, 60% exhibited SH. Internalizing symptoms, emotion regulation, and body investment were assessed using the Youth Self-Report (YSR), the Difficulties in Emotion Regulation Scale (DERS), and the Body Investment Scale (BIS).

resultsResults revealed that LP-GD adolescents had significantly higher emotion dysregulation (ED), particularly in the Strategies domain of the DERS (

conclusionsThese findings supported the hypothesis that LP-GD adolescents and youths with a history of SH showed more pronounced emotion regulation difficulties and internalizing symptoms, further emphasizing the need for early intervention programs targeting both GD and co-occurring mental health problems.

Indexed as

adolescentsbody imageemotional dysregulationgender dysphoriainternalizing disordersself-harm behaviors

Identifiers

PMID40126236
PMCPMC11932281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.