Evidence map›Paper›PMID 40126220›Full record

ArticleHematology reports2025

Feasibility of Intensive Chemotherapy in Hereditary Spherocytosis.

Carrai Valentina, Giubbilei Cristina, Ciceri Manuel, D'Angelo Simona, Nassi Luca, Sordi Benedetta, Vannucchi Alessandro Maria, Puccini Benedetta

Abstract readCase Reports
In one paragraph

Article in Hematology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carrai ValentinaHematology Unit, Careggi University Hospital, 50134 Florence, Italy.
Giubbilei CristinaHematology Unit, Careggi University Hospital, 50134 Florence, Italy.ORCID 0009-0004-0411-9962
Ciceri ManuelHematology Unit, Careggi University Hospital, 50134 Florence, Italy.
D'Angelo SimonaHematology Unit, Careggi University Hospital, 50134 Florence, Italy.
Nassi LucaHematology Unit, Careggi University Hospital, 50134 Florence, Italy.
Sordi BenedettaHematology Unit, Careggi University Hospital, 50134 Florence, Italy.
Vannucchi Alessandro MariaHematology Unit, Careggi University Hospital, 50134 Florence, Italy.ORCID 0000-0001-5755-0730
Puccini BenedettaHematology Unit, Careggi University Hospital, 50134 Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study presents a young man with hereditary spherocytosis (HS) who underwent intensive chemotherapy for newly diagnosed diffuse large B-cell lymphoma (DLBCL) and achieved complete remission. This case challenges the idea of HS as a barrier to standard DLBCL treatment. DISCUSSION: By meticulously monitoring blood counts and providing timely transfusions, the team successfully mitigated potential complications associated with chemotherapy-induced stress on red blood cells.

conclusionsThis experience underscores the importance of a multidisciplinary approach and tailored treatment plans for patients with co-existing conditions, suggesting that HS should not automatically disqualify them from potentially curative therapies for aggressive lymphomas.

Indexed as

chemotherapydiffuse large B cell lymphomahereditary spherocytosisrare disorders

Identifiers

PMID40126220
PMCPMC11932310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.