Evidence map›Paper›PMID 40125789›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Copper-Based Photothermal-Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self-Amplified Cuproptosis for Synergistic Cancer Therapy.

Runzi Cheng, Zhenhao Li, Weican Luo, Hongwu Chen, Tingting Deng, Zhenqi Gong, Qing Zheng, Baizhi Li, Yongming Zeng, Huaiming Wang and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Emerging copper-based hollow nanoplatforms for cancer treatment.International journal of pharmaceutics: X · 2026
    Review
  2. Ultrasound-activated CuJournal of nanobiotechnology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Runzi ChengDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.ORCID https://orcid.org/0000-0002-2868-7030
Zhenhao LiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Weican LuoDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Hongwu ChenDepartment of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Tingting DengShantou University Medical College, Shantou, 515041, China.
Zhenqi GongDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Qing ZhengDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Baizhi LiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Yongming ZengDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Huaiming WangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Cong HuangDepartment of Ultrasound, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515220192Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515010665Beijing Innovation Center for Engineering Science and Advanced Technology, Peking University KC2023-JX-0186- FM047Medical Science and Technology Foundation of Guangdong Province A2024042
6 · The paper itself

Abstract

Studies show that intracellular accumulation of copper ions causes cuproptosis, potentially enhancing anticancer immunity. However, the induction of cuproptosis inevitably faces challenges due to low intracellular copper deliver efficiency and collateral damage to normal tissues. This paper presents a self-amplified cuproptosis nanoplatform (CEL NP) composed of Cu

Indexed as

CopperNeoplasmsPhotothermal TherapyAnimalsCell Line, TumorHumansMiceNanospheresTumor MicroenvironmentCoppercuproptosiselesclomolimmunogenic cell deathphotothermally responsive

Identifiers

PMID40125789
PMCPMC12097029

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.