Evidence map›Paper›PMID 40125734›Full record

ArticlePsychological medicine2025

Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths.

Andre Zugman, Grace V Ringlein, Emily S Finn, Krystal M Lewis, Erin Berman, Wendy K Silverman, Eli R Lebowitz, Daniel S Pine, Anderson M Winkler

Abstract read
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Andre ZugmanEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6126-7759
Grace V RingleinEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Emily S FinnPsychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
Krystal M LewisEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Erin BermanEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Wendy K SilvermanChild Study Center, Yale University, New Haven, CT, USA.
Eli R LebowitzChild Study Center, Yale University, New Haven, CT, USA.
Daniel S PineEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Anderson M WinklerEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Workforce Development CoreU54HG013247 · NHGRI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Gladys E. Maestre · 2023 to 2026
$10.5M
Intramural NIH HHS ZIA MH002781NHGRI NIH HHS U54 HG013247
6 · The paper itself

Abstract

backgroundBecause pediatric anxiety disorders precede the onset of many other problems, successful prediction of response to the first-line treatment, cognitive-behavioral therapy (CBT), could have a major impact. This study evaluates whether structural and resting-state functional magnetic resonance imaging can predict post-CBT anxiety symptoms.

methodsTwo datasets were studied: (A) one consisted of

resultsThe main model showed a MAE of approximately 3.5 (95% CI: [3.1-3.8]) points, an

conclusionsThe analysis showed that models based on earlier promising results failed to predict clinical outcomes. Despite the small sample size, this study does not support the extensive use of CPM to predict outcomes in pediatric anxiety.

Indexed as

Anxiety DisordersBrainCognitive Behavioral TherapyConnectomeAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleTreatment OutcomeanxietyCBTfMRIresting-state

Identifiers

PMID40125734
PMCPMC12080668

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.