ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Piezoelectric Nanofibrous Scaffolds for Promoting the Growth of Spiral Ganglion Neurons via Acoustic Stimulation.Smart medicine · 2026Article
- Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss.Frontiers in molecular neuroscience · 2026Review
- The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The auditory circuit primarily consists of peripheral auditory organs and auditory neural pathways. Hearing loss (HL), as reported by the World Health Organization, affects more than one in eight people worldwide, often leading to severe dysfunction that detrimentally impacts patients' quality of life. Therefore, auditory reconstruction has emerged as a persistent research hotspot and challenge within the biomedical field. Traditional methods for auditory reconstruction, such as drug therapy, hearing aids, cochlear implants (CIs), and so on. To a certain extent, it can help patients with HL improve their hearing status. However, they possess inherent advantages and limitations. Recent advancements in biomaterials, gene editing, stem cells, organoids, and other technologies have ushered in new prospects for the treatment of hearing impairment. This review focuses on the potential of innovative technologies in biomaterials, stem cells, and gene editing in hearing recovery. It reviews the current research status of inner ear hair cell (HC) regeneration, spiral ganglion neuron (SGN) regeneration, and inner ear organoid construction in the auditory loop. Furthermore, the review discusses the challenges associated with these approaches and explores potential future directions, aiming to furnish a comprehensive reference for both research and clinical applications in the domain of peripheral auditory restoration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.