Evidence map›Paper›PMID 40125694›Full record

ArticleHistology and histopathology2025

A low nuclear-to-cytoplasmic ratio of VDR expression is an independent prognostic marker in breast cancer.

Charlotte Schubert, Theresa Vilsmaier, Falk Batz, Vincent Cavaillès, Sophie Sixou, Thomas Kolben, Sarah Meister, Christina Buschmann, Friederike Hagemann, Sven Mahner and 4 more

Abstract read
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In one paragraph

Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Charlotte SchubertDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Theresa VilsmaierDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Falk BatzDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Vincent CavaillèsIRCM-Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier, France.
Sophie SixouFaculté des Sciences Pharmaceutiques, Université Paul Sabatier Toulouse III, Toulouse, France.
Thomas KolbenDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Sarah MeisterDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Christina BuschmannDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Friederike HagemannDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Sven MahnerDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Melitta B KöpkeDepartment of Obstetrics and Gynecology, University Hospital Augsburg, Augsburg, Germany. Udo.jeschke@med.uni-augsburg.det.
Nina DitschDepartment of Obstetrics and Gynecology, University Hospital Augsburg, Augsburg, Germany. Udo.jeschke@med.uni-augsburg.det.
Udo JeschkeDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.
Alaleh Zati ZehniDepartment of Obstetrics and Gynecology, LMU University Hospital, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this retrospective study was to analyze the prognostic value of cytoplasmic versus nuclear expression of the vitamin D receptor (VDR) in breast cancer (BC) tissue samples and to relate the results to clinicopathological parameters. VDR expression was assessed in 319 primary breast cancer patients using the Remmele and Stegner immunoreactive scoring (IRS) system. Follow-up data were obtained from the Munich Cancer Registry. The correlation with overall survival (OS) and disease-free survival (DFS) was calculated using univariate and multivariate analyses. Correlation analysis revealed a correlation between nuclear VDR expression and improved outcomes for both OS (

Indexed as

Biomarkers, TumorBreast NeoplasmsCell NucleusCytoplasmReceptors, CalcitriolAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMiddle AgedPrognosisRetrospective StudiesBiomarkers, TumorReceptors, CalcitriolVDR protein, human

Identifiers

PMID40125694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.