Evidence map›Paper›PMID 40125518›Full record

ArticleFrontiers in cellular and infection microbiology2025

Decoy receptor 3 as a prognostic biomarker for sepsis and septic shock according to the Sepsis-3 definitions.

Long Chen, Xiao Lin, Xing Yu, Chunxia Yang, Rui Li, Qingqing Guo, Jingshi Shi, Xiuyu Liao, Xiaoli Chen, Zengyi Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Long Chen *Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Fudan University, Shanghai, China.
Xiao Lin *Intensive Care Unit, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Xing Yu *Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Chunxia Yang *Intensive Care Unit, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Rui LiDepartment of Neurosurgery & Neurocritical Care, Huashan Hospital, Fudan University, Shanghai, China.
Qingqing GuoIntensive Care Unit, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jingshi ShiIntensive Care Unit, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Xiuyu LiaoIntensive Care Unit, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Xiaoli ChenIntensive Care Unit, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Zengyi MaDepartment of Neurosurgery & Neurocritical Care, Huashan Hospital, Fudan University, Shanghai, China.
Jiandong LinIntensive Care Unit, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The present study was conducted to reappraise the prognostic value of decoy receptor 3 (DcR3) for patients with sepsis and septic shock according to the latest Sepsis-3 definitions. Methods: Subjects suffering from sepsis or septic shock were enrolled within 6 h of admission. The Sequential Organ Failure Assessment (SOFA) score and the plasma levels of DcR3, C-reactive protein, procalcitonin, and interleukin-6 were measured. Group comparisons were made based on the survival status on day 28 after onset. Predictors of mortality were assessed using the Cox proportional hazard models, and survival curves were plotted with the Kaplan-Meier method. Discriminative performances of single and combined indicators were evaluated via the areas under receiver operating characteristic curves. Results: Among 143 eligible sepsis cases, 77 developed septic shock, and the 28-day mortality rates were 32.2% and 45.5%, respectively. Regardless of the population (all sepsis or septic shock), non-survivors exhibited significantly higher DcR3 levels compared to survivors (median 4.19 vs. 2.64 ng/mL and 4.37 vs. 3.18 ng/mL, respectively; Conclusions: DcR3 is a valuable prognostic biomarker for sepsis and septic shock, offering the potential to predict 28-day mortality in clinical settings.

Indexed as

BiomarkersReceptors, Tumor Necrosis Factor, Member 6bSepsisShock, SepticAgedAged, 80 and overC-Reactive ProteinFemaleHumansInterleukin-6Kaplan-Meier EstimateMaleMiddle AgedOrgan Dysfunction ScoresProcalcitoninPrognosisBiomarkersC-Reactive ProteinInterleukin-6ProcalcitoninReceptors, Tumor Necrosis Factor, Member 6bTNFRSF6B protein, humanbiomarkerdecoy receptor 3organ dysfunctionprognosissepsisseptic shock

Identifiers

PMID40125518
PMCPMC11925903

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