ArticlePlastic and reconstructive surgery. Global open2025
The Inflammatory Reaction to Silicone Implants: Polyurethane Foam Versus Nanotextured Surface-An Experimental Study in Rats.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The interaction between the surface of the implant and the human body results in a local and systemic inflammatory reaction that leads to the formation of a peri-implant capsule and entails complications. This study aimed to evaluate and compare the local and systemic inflammatory reactions of silicone implants coated with polyurethane foam and those with a nanotextured surface. Methods: Using indirect enzyme-linked immunosorbent assay, the levels of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) were measured in the serum and per-implant capsule of rats submitted to surgical placement of the 2 different types of implants. The statistical analysis was conducted within each group, comparing the parameters according to the times at which the rats were euthanized at 3 distinct durations of exposure (30, 60, and 90 d). Results: The results show that at both 30 and 60 days, there was no significant increase in the levels of markers in either group; however, a change becomes evident at 90 days. The nanotextured surface showed a decreased production of inflammatory markers at 30 and 60 days as compared with the polyurethane group. Nevertheless, at 90 days, there is a marked increase in these markers observed in the nanotextured group and a decrease in the polyurethane group, yet without any statistical significance between either group at that time. Conclusions: After a lapse of an extended period of time (90 d), nanotextured surface implants cause a local and systemic inflammatory reaction similar to those with a polyurethane foam surface.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.