ArticleCureus2025
A Nutraceutical Approach Using Herbs, Vitamins, Trace Elements, and Amino Acids for the Treatment of Insomnia Disorder and Anxiety: An Eight-Week Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives This prospective, observational, single-arm, open-label study aimed to evaluate the efficacy and safety of a phytotherapeutic and nutraceutical compound in the treatment of patients with insomnia disorder (ID) associated with anxiety. Methods The study was conducted on a clinical sample of 28 patients (6 men, 21.4%, and 22 women, 78.6%) suffering from ID, associated with a state of anxiety. The sample study was clinically evaluated at baseline (T0) and after four (T1) and eight weeks (T2) of phytotherapeutic and nutraceutical treatment using the following self-administered questionnaires: Pittsburgh Sleep Quality Index, State and Trait Anxiety Inventory, Insomnia Severity Index, Depression and Anxiety Scale Short Form - 21, Beck Depression Inventory, Fatigue Severity Scale, Rapid Stress Assessment, Patient Global Impression of Improvement - Severity and short form-36. Results The effect of treatment over time was statistically significant for all measures considered including the short form-36 subscales 3 and 5, with the exception of the other short form-36 subscales and fatigue severity scale. Linear regression reported a significant association only between T1 and T2 scores (p<0.05). No correlations were found with age except for the test short form-36 subscale 5 (Pearson r=0.421; p =0.036 and tau Kendal =0.311; p=0.033) and no correlation for the level of education. No safety concerns were reported in the sample study. Conclusion The results of this study support the clinical efficacy and safety of the phytotherapeutic and nutraceutical study compound for the treatment of ID in patients with anxiety symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.