ArticleCureus2025
Treating a Non-mixed Neuroendocrine Colorectal Tumor Under Mixed Neuroendocrine Neoplasm (MiNEN) Protocols: A Case Report of Successful Outlier Management.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Small-cell neuroendocrine carcinoma of the descending colon in a young adult: a case report.Frontiers in oncology · 2026Article
- Lymph node metastasis of grade 1 neuroendocrine tumor from rectal mixed neuroendocrine non-neuroendocrine neoplasm: A case report.The Journal of international medical research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 65-year-old male presented after a positive Cologuard testing. He was asymptomatic at presentation, with no reported complaints of fever, chills, abdominal pain, diarrhea, constipation, hematochezia, or unexpected weight loss. CT imaging of the abdomen and pelvis revealed a 2 cm mass at the rectosigmoid junction with a single enlarged lymph node nearby measuring 2.7 x 1.6 cm, raising suspicion for regional metastatic adenopathy. He underwent a colonoscopy, which confirmed a rectosigmoid mass. Biopsy results showed adenocarcinoma of the colon. Consequently, the patient was scheduled for a laparoscopic sigmoidectomy with low anterior resection. The pathology of the surgical specimen confirmed adenocarcinoma, moderately differentiated, associated with a component of poorly differentiated large cell neuroendocrine carcinoma, with the neuroendocrine component best developed in the lymph node metastasis. Although the patient did not meet the standard criteria for mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) tumors, treatment was administered using chemotherapeutic agents typically reserved for MiNENs. He was treated with platinum-based doublet with good response and has been in remission for one and a half years. This report highlights the importance of flexible therapeutic approaches when pathology marginally deviates from the standard established criteria, illustrating that tailoring treatment to the specific pathology can provide considerable patient benefits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.