Evidence map›Paper›PMID 40125083›Full record

ArticleJournal of inflammation research2025

Elucidating Molecule-Crosstalk of Neutrophil Extracellular Traps Between Cardiovascular Disease and Psoriasis: Insights Into Mendelian Randomization, Single-Cell RNA Analysis, Shared Targets and the Role of Resveratrol.

Xiaojun Jin, Yun Zhang, Gaofeng Qin, Xinyan Fang, Xinnan Zhang, Jialin Sun, Min Zhou, Xuecheng Tong, Yuan Xue, Hui Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaojun Jin *Department of Clinical Technology Laboratory, Changzhou Clinical College of Xuzhou Medical University, Changzhou Third People's Hospital, Changzhou, Jiangsu, 213000, People's Republic of China.
Yun Zhang *Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, 510000, People's Republic of China.
Gaofeng QinDepartment of Life Science Institute, Jinzhou Medical University, Jinzhou, Liaoning, 121001, People's Republic of China.
Xinyan FangSchool of Statistics, East China Normal University, Shanghai, 200062, People's Republic of China.
Xinnan ZhangSchool of Teacher Education, Ningbo University, Ningbo, Zhejiang, 315000, People's Republic of China.
Jialin SunSchool of Statistics, East China Normal University, Shanghai, 200062, People's Republic of China.
Min ZhouDepartment of Clinical Technology Laboratory, Changzhou Clinical College of Xuzhou Medical University, Changzhou Third People's Hospital, Changzhou, Jiangsu, 213000, People's Republic of China.
Xuecheng TongDepartment of Clinical Technology Laboratory, Changzhou Clinical College of Xuzhou Medical University, Changzhou Third People's Hospital, Changzhou, Jiangsu, 213000, People's Republic of China.ORCID 0009-0007-3462-4742
Yuan XueDepartment of Clinical Technology Laboratory, Changzhou Clinical College of Xuzhou Medical University, Changzhou Third People's Hospital, Changzhou, Jiangsu, 213000, People's Republic of China.ORCID 0000-0002-5428-0058
Hui YangDepartment of Clinical Technology Laboratory, Changzhou Clinical College of Xuzhou Medical University, Changzhou Third People's Hospital, Changzhou, Jiangsu, 213000, People's Republic of China.
Weihong TianDepartment of Clinical Technology Laboratory, Changzhou Clinical College of Xuzhou Medical University, Changzhou Third People's Hospital, Changzhou, Jiangsu, 213000, People's Republic of China.ORCID 0000-0003-2582-931X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Left ventricular hypertrophy (LVH) associated with hypertension and psoriasis (PSO) are linked by poor prognosis. Neutrophil extracellular traps (NETs) are implicated in both conditions, but the mechanisms remain unclear. Methods: We integrated bulk and single-cell RNA sequencing, mendelian randomization, immune microenvironment analysis, and molecular docking to explore the molecular interactions between LVH and PSO, focusing on NET-related pathways. Prediction models were also developed, and gene function was validated through in vivo and in vitro experiments. Results: Our findings identified NETs-associated genes, AKT serine/threonine kinase 1 ( Conclusion: This study highlights molecular pathways linking LVH and PSO, suggesting novel targets for treating cardiac involvement in PSO patients with LVH.

Indexed as

hypertrophymolecular crosstalkmolecular dockingneutrophil extracellular trapspsoriasis

Identifiers

PMID40125083
PMCPMC11929043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.