Evidence map›Paper›PMID 40125057›Full record

ArticleIndian dermatology online journal

Targeted Filaggrin Gene (

Arun Somasundaram, Minu Jose Chiramel, Aaron Chapla, Dharshini Sathishkumar, Rekha Athiyarath, Lydia Mathew, Sumita Danda

Abstract read
In one paragraph

Article in Indian dermatology online journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arun SomasundaramDepartment of Dermatology, Venereology and Leprology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Minu Jose ChiramelDepartment of Dermatology, Venereology and Leprology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Aaron ChaplaDepartment of Endocrinology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Dharshini SathishkumarDepartment of Dermatology, Venereology and Leprology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Rekha AthiyarathDepartment of Medical Genetics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Lydia MathewDepartment of Dermatology, Venereology and Leprology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Sumita DandaDepartment of Medical Genetics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Filaggrin deficiency causes early-onset atopic dermatitis (AD), extrinsic AD, persistent and severe disease, palmoplantar hyper linearity, keratosis pilaris, and increased risk of hand eczema. There is a paucity of data on the prevalence and types of variation in the filaggrin gene ( Aim and Objectives: To study the prevalence and characteristics of filaggrin mutations in Indian children affected with AD and to attempt a genotype-phenotype correlation. Materials and Methods: A pilot study was done among Indian children with AD aged 4-16 years, attending the Pediatric Dermatology outpatient department between February and September 2022 (7 months). Long-range polymerase chain reaction target enrichment and next-generation sequencing were used to sequence the complete Results: Among the 30 recruited children with AD, 28 genetic variants in exon 3 of Limitation: Small sample size. Conclusion: Significant

Indexed as

Atopic dermatitisatopic eczemafilaggrin polymorphismsFLGIndian childrennext-generation sequencing

Identifiers

PMID40125057
PMCPMC11927984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.