Evidence map›Paper›PMID 40124979›Full record

ArticleClinical parkinsonism & related disorders2025

Bi-pallidal deep brain stimulation as an effective therapy in atypical two-stage evolution adult-onset

Georges-Junior Kahwagi, Cécile Hubsch, Lydie Burglen, Jean-Philippe Brandel, Sophie Sangla, Clément Desjardins

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Georges-Junior KahwagiDepartment of Neurology, Movement Disorders Unit, Hospital Foundation Adolphe de Rothschild, Paris, France.
Cécile HubschDepartment of Neurology, Movement Disorders Unit, Hospital Foundation Adolphe de Rothschild, Paris, France.
Lydie BurglenCerebellar Malformations and Congenital Diseases Reference Center and Neurogenetics Lab, Department of Genetics, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France.
Jean-Philippe BrandelDepartment of Neurology, Movement Disorders Unit, Hospital Foundation Adolphe de Rothschild, Paris, France.
Sophie SanglaDepartment of Neurology, Movement Disorders Unit, Hospital Foundation Adolphe de Rothschild, Paris, France.
Clément DesjardinsDepartment of Neurology, Movement Disorders Unit, Hospital Foundation Adolphe de Rothschild, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an adult-onset KMT2B-related dystonia with a two-stage evolution: focal cervical onset followed by rapid generalization. Whole genome sequencing identified a likely pathogenic KMT2B variant. Bi-pallidal deep brain stimulation led to an 83% motor improvement, highlighting its therapeutic potential in late-onset atypical two-stage evolution KMT2B-dystonia.

Indexed as

Deep brain stimulationDystoniaGeneticKMT2B

Identifiers

PMID40124979
PMCPMC11930154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.