Evidence map›Paper›PMID 40124972›Full record

ArticleEFSA journal. European Food Safety Authority2025

Risk assessment considerations for RNAi-based genetically modified plants.

European Food Safety Authority (EFSA), Francisco Barro, Albert Braeuning, Tilemachos Goumperis, Aleksandra Lewandowska, Simon Moxon, Nikoletta Papadopoulou, Elena Sánchez-Brunete

Abstract read
In one paragraph

Article in EFSA journal. European Food Safety Authority, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Creating resistance to the whiteflyFrontiers in plant science · 2026
    Article
  6. Article
  7. Risk assessment considerations for RNAi-based genetically modified plants.EFSA journal. European Food Safety Authority · 2025
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

European Food Safety Authority (EFSA)
Francisco Barro
Albert Braeuning
Tilemachos Goumperis
Aleksandra Lewandowska
Simon Moxon
Nikoletta Papadopoulou
Elena Sánchez-Brunete

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk assessment (RA) requirements for genetically modified plants (GMPs) are defined in Regulation (EU) No 503/2013 and the EFSA guidance on the RA of food and feed from GM plants (EFSA GMO Panel, 2011). When a GMP is developed to silence transcripts by RNA interference (RNAi), some specific additional analysis needs to be provided by the applicant. This guidance describes the requirements and recommendations for the GMP applications submitted to EFSA. It covers the molecular characterisation, focusing on bioinformatic analysis and confirmation of the trait, as well as the food and feed safety and dietary exposure assessment of RNAi-based GMPs. This document replaces the GMO panel strategy for the risk assessment of RNAi off targets in plants, described in Annex II to the minutes of the 118th Plenary meeting of the Scientific Panel on GMO and takes into account the current knowledge on the mechanisms of RNAi in plants.

Indexed as

genetically modified organismsmolecular characterisationnon‐coding RNAoff‐targetrisk assessmentRNA interference

Identifiers

PMID40124972
PMCPMC11926569

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.