Evidence map›Paper›PMID 40124675›Full record

ArticleCurrent opinion in physiology2025

Sex-Specific Effects of Environmental Pollutants on Pulmonary Immune Responses.

Sylvia S Sanchez, Fenna C M Sillé

Abstract read
In one paragraph

Article in Current opinion in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sylvia S SanchezDepartment of Environmental Health and Engineering, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States of America.
Fenna C M SilléDepartment of Environmental Health and Engineering, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States of America.

Funding

MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
Pilot Project ProgramP30ES032756 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 2022 to 2026
$6.0M
Long-term Effects of Early-Life Arsenic Exposure on ImmunityR00ES024808 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI SILLE, FENNA · 2017 to 2019
$838k
NHLBI NIH HHS T32 HL007534NIEHS NIH HHS P30 ES032756NIEHS NIH HHS R00 ES024808
6 · The paper itself

Abstract

Environmental pollutants can adversely impact various physiological processes, affecting systems such as the respiratory and immune systems. Immune responses are influenced by various factors including age, hormonal status, genetic background, and notably, sex, with effects extending to both innate and adaptive immunity. External factors, like environmental pollutants, can also disrupt innate and/or adaptive immunity and compromise pathogen recognition and memory against future infections. Furthermore, environmental pollutants can play a pivotal role in the development and exacerbation of many chronic respiratory diseases. It is becoming increasingly evident that environmental pollutants elicit sex-specific effects across different species. This review highlights recent findings on the intricate interplay between sex differences and immune-related effects induced by environmental pollutants, with a particular focus on the dysregulation of pulmonary immune responses.

Indexed as

asthmahormonesimmune systemimmunomodulatorsinfectionspollutants

Identifiers

PMID40124675
PMCPMC11928163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.