Evidence map›Paper›PMID 40124666›Full record

ArticleCrystal growth & design2025

Insight into the Precipitation Inhibition of Polymers within Cocrystal Formulations in Solution Using Experimental and Molecular Modeling Techniques.

Peace Alinda, Adolfo Botana, Mingzhong Li

Abstract read
In one paragraph

Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Peace AlindaLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, U.K.
Adolfo BotanaJEOL (U.K.) LTD., Welwyn Garden City AL7 1LT, U.K.
Mingzhong LiLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, U.K.ORCID https://orcid.org/0000-0002-9532-9049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the role of various polymers as precipitation inhibitors in solutions of flufenamic acid (FFA) and its cocrystals with theophylline (FFA-TP) and nicotinamide (FFA-NIC). Through a combination of NMR spectroscopy, molecular dynamics simulations, and nucleation studies using Crystal16, we evaluated the effects of polyethylene glycol (PEG), polyvinylpyrrolidone-vinyl acetate (PVP-VA), and soluplus (SOL), both individually and in combinations, on the nucleation, diffusion, and self-association of FFA molecules in solution.

Identifiers

PMID40124666
PMCPMC11926783

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.