ArticleAmerican journal of clinical and experimental urology2025
Radical prostatectomy is associated with favorable outcomes in patients over 80 years old.
Article in American journal of clinical and experimental urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Patient-reported early continence recovery after robot-assisted radical prostatectomy in elderly men.Journal of robotic surgery · 2026Article
- Global trends in prostate cancer burden among adults aged 80 years and older from 1990 to 2021 based on the global burden of disease 2021.Discover oncology · 2025Article
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11 authors.
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Abstract
INTRODUCTION/
backgroundAlthough surgery is less commonly selected as treatment for localized prostate cancer (PCa) as patients age, outcomes among older patients treated with radical prostatectomy remain unclear. The objective of this study was to compare survival across non-definitive therapy (NDT), radiotherapy, and radical prostatectomy (RP) among men older than 80 years old. MATERIALS AND
methodsUsing the SEER-17 database, we identified patients ≥80 years at diagnosis with localized prostate cancer in 2000-2021 who were initially managed with NDT, radiotherapy, or RP. We compared overall (OS) and prostate cancer-specific survival (PCSS).
resultsWe identified 53,437 patients with PCa≥80 years including 35,728 (68.2%) who underwent NDT, 15,906 (30.4%) treated with radiotherapy, and 736 (1.4%) with RP. The median age was 83 years (IQR: 81-85) and median PSA at diagnosis was 10.7 ng/mL (IQR: 6.7-19.9). Median OS was 66, 102 and 116 months for patients managed with NDT, radiotherapy, and RP, respectively (OS-P<0.01, PCSS-P<0.01). Cox regression revealed that compared to NDT, radiotherapy (OS-baseline adjusted hazard ratio: 0.48, 95% CI: 0.45-0.51, P<0.01; PCSS-baHR: 0.44, 95% CI: 0.38-0.51, P<0.01) and RP were associated with higher OS and PCSS (OS-baHR: 0.33, 95% CI: 0.24-0.46, P<0.01; PCSS-baHR: 0.19, 95% CI: 0.08-0.42, P<0.01).
conclusionThese findings suggest that well-selected patients ≥80 years may experience favorable survival following RP.
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