Trial reportDrug design, development and therapy2025
Effect of Esketamine-Based Opioid-Sparing Anesthesia Protocol on the Quality of Early Recovery After Urological Surgery: A Randomized Clinical Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative safety of esketamine in procedural sedation and analgesia: a systematic review and network meta-analysis.BMC anesthesiology · 2026Pooled it
- Esketamine vs. sufentanil for quality of recovery after outpatient gynecological surgery: a randomized clinical trial.Annals of medicine · 2026Trial
- Esketamine for Postoperative Multimodal Analgesia in Laparoscopic Surgery: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The quality of postoperative recovery under enhanced recovery after surgery protocols has always been the focus of anesthesiologists. It has been proven that esketamine application during the perioperative period can reduce the use of opioid drugs and improve the quality of postoperative recovery. The present study explored the effect of the esketamine-based opioid-sparing anesthesia protocol on the quality of postoperative recovery in patients undergoing elective urological surgery. Patients and Methods: A randomized, double-blind, controlled clinical trial was adopted. Patients aged 18-65 years, with American Society of Anesthesiologists physical status grades I-III, scheduled for elective laparoscopic partial nephrectomy or unilateral nephrectomy in urological surgery, were randomly divided into the OSA group and the control group. The OSA group received 0.25 mg/kg of esketamine for anesthesia induction during the operation, and maintenance was carried out at a rate of 0.125 mg·kg⁻¹·h⁻¹. The primary outcome measure was the Quality of Recovery Scale-15 score 24 hours after the operation. Results: The total Quality of Recovery Scale-15 score was significantly higher in the OSA than in control groups 24 hours after the operation (114 [108, 116] vs 106 [102, 109], Conclusion: The esketamine-based opioid-sparing anesthesia protocol can improve the quality of early postoperative recovery and the level of anesthesia recovery, and accelerate rehabilitation in patients undergoing elective urological surgery.
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