Evidence map›Paper›PMID 40124522›Full record

ArticleiScience2025

The m6A reader HNRNPC is a key regulator in DSS-induced colitis by modulating macrophage phenotype.

Xiaohui Fang, Yu Zhang, Ziliang Ke, Yang Zhang, Yiken Lin, Yibo Huang, Jianhua Zhou, Huiting Su, Jun Xu, Yulan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. mFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaohui FangDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Yu ZhangDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Ziliang KeDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Yang ZhangDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Yiken LinDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Yibo HuangDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Jianhua ZhouInstitute of Clinical Molecular Biology & Central Laboratory, Peking University People's Hospital, Beijing 100044, China.
Huiting SuInstitute of Clinical Molecular Biology & Central Laboratory, Peking University People's Hospital, Beijing 100044, China.
Jun XuDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.
Yulan LiuDepartment of Gastroenterology, Peking University Peoples Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing 100044, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

m6A regulators were demonstrated to modulate the functions of intestinal epithelial and immune cells in the ulcerative colitis. This study aimed to elucidate whether and how the m6A reader heterogeneous nuclear ribonucleoprotein C (HNRNPC) regulates macrophage function in the colitis. We observed elevated HNRNPC in the inflammatory Raw264.7 cells and macrophages in the dextran sodium sulfate (DSS)-induced colitis. Knocking down HNRNPC can mitigate LPS-induced activation of macrophages

Indexed as

Cell biologyImmune responseMolecular biology

Identifiers

PMID40124522
PMCPMC11927749

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.